Intermediates for making ring-substituted 2-amino-1,2,3,4-tetrah

Details Intermediates for making ring-substituted 2-amino-1,2,3,4-tetrah Intermediates for making ring-substituted 2-amino-1,2,3,4-tetrah

1993-10-21

1995-06-20

Chang, Celia

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564340, 558405, C07C22302

Patent

active

054262267

ABSTRACT:
The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes which exhibit binding activity at the serotonin 1A receptor. An intermediate for preparing the novel compounds have the following formula: ##STR1## wherein R, R.sub.1 and R.sub.9, are as defined in the specification.

REFERENCES:
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patent: 5196454 (1993-03-01), Grauert
patent: 5214156 (1993-05-01), Andersson
patent: 5286753 (1994-02-01), Schaus
Arvidsson et al "8-hydroxy-2-alkylamino tetralin and related compounds as central 5-H-tryptamine Receptor Agonists" J. Med Chem. 27 45-51 (1984).
Glennon, J. Med. Chem., 30, 1-12 (1987).
CA, 110, 57322a (1989).

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