Intermediates for making 2-oxindole-1-carboxamides

Details Intermediates for making 2-oxindole-1-carboxamides Intermediates for making 2-oxindole-1-carboxamides

1989-05-25

1990-08-28

Ceperley, Mary E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544333, 544405, 546270, 546273, 548127, 548134, 548136, 548181, 548214, 548235, 548248, 548249, 548336, 548374, 548450, 548466, 548468, 548486, C07D491056, C07D20942

Patent

active

049527037

ABSTRACT:
Preparation of 2-oxindole-1-carboxamides by reaction of 2-oxindoles with trichloracetyl isocyanate to produce novel N-trichloroacetyl-2-oxindole-1-carboxamides which are then hydrolyzed to 2-oxindole-1-carboxamides useful as analgesic and anti-inflammatory agents and/or intermediates for such agents.

REFERENCES:
patent: 4658037 (1987-04-01), Kadin
patent: 4665194 (1987-05-01), Crawford
Graf, Angew. Chem. Internat. Edit. 7, 172-182 (1968).

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