Intermediates for making 1-(3-benzyloxyphenyl)-1,1-dimethylhepta

Details Intermediates for making 1-(3-benzyloxyphenyl)-1,1-dimethylhepta Intermediates for making 1-(3-benzyloxyphenyl)-1,1-dimethylhepta

1981-11-02

1982-11-23

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568647, 568631, C07C 43225, C07C 4323

Patent

active

043607004

ABSTRACT:
Process for making 1-(3-benzyloxyphenyl)-1,1-dimethylheptane, a valuable intermediate for the preparation of analgesic agents, which comprises benzylation of 3-hydroxyacetophenone to produce 3-benzyloxyacetophenone which is converted to 1-(3-benzyloxyphenyl)-1-methylheptan-1-ol via Grignard reaction with n-hexylmagnesium bromide; chlorination of said heptanol by reaction with hydrogen chloride followed by methylation of the thus-produced 1-(3-benzyloxyphenyl)-1-chloro-1-methylheptane with trimethylaluminum.

REFERENCES:
patent: 4284829 (1981-08-01), Althuis et al.
patent: 4285867 (1981-08-01), Johnson et al.
Miller, Jour. Org. Chem., vol. 31 (1966) 908-912.
Kennedy, Jour. Org. Chem., vol. 35 (1970) 532-535.
Weygand/Hilgetag, Preparative Org. Chem. (1972) 214-219.

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