Intermediates for isopropyl 3S-amino-2R-hydroxy-alkanoates

Details Intermediates for isopropyl 3S-amino-2R-hydroxy-alkanoates Intermediates for isopropyl 3S-amino-2R-hydroxy-alkanoates

1991-07-18

1992-11-24

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560425, 560170, C07C23308, C07C23311, C07C23305

Patent

active

051664003

ABSTRACT:
Process and intermediates for isopropyl 3S-amino-4-cyclohexyl-2R-hydroxybutyrate and 3S-amino-2R-hydroxy-5-methylhexanoate from R-malic acid. These products are of known utility in the synthesis of certain renin inhibitors.

REFERENCES:
patent: 4599198 (1986-07-01), Hoover
patent: 4656269 (1987-04-01), Iizuka et al.
patent: 4711958 (1987-12-01), Iizuka et al.
patent: 4814342 (1989-03-01), Hoover et al.
Johnson, J. Med. Chem. 25, 605-610 (1982).
Rich et al., J. Org. Chem. 45, 2288-2290 (1980).
Tobe et al., Agric. Biol. Chem. 43, 591-596 (1979).
Nishizawa et al., J. Med. Chem. 20, 510-515 (1977).
Miller et al., J. Org. Chem. 47, 4928-4933 (1982).
Seebach et al., Helv. Chim. Acta. 63, 197-200 (1980).
Seebach et al., Organic Synthesis 63, 109-120 (1984).
Gao et al., J. Am. Chem. Soc. 110, 7538-7539 (1988).
Rabin, et al., Biochemistry 7, 377-388 (1968).
Chemical Abstracts 68:36934a.

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