Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-03-01
2011-03-01
Chandrakumar, Nizal S (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07897769
ABSTRACT:
The present invention provides novel fluorophilic compounds having structure VIwherein R1is a C2-C20aliphatic, a C3-C20cycloaliphatic, or a C3-C20aromatic radical comprising at least one functional group susceptible to reaction with nucleophilic fluoride ion or an electrophilic fluorinating agent; R2is a C1-C10aliphatic radical, or a C3-C10cycloaliphatic radical; R3is hydrogen or a C1-C10aliphatic radical; and R4is hydrogen or a C1-C10aliphatic radical. The fluorophilic compounds are provided in both racemic and enantiomerically enriched forms and are useful as intermediates in the preparation of novel PET imaging agents and probes useful in the discovery and performance assessment of PET imaging agents. The fluorophilic compounds are particularly useful in the preparation of PET imaging agents and probes having a high affinity for VMAT-2, a biomarker implicated in human diabetes and other illnesses such as Parkinson's disease.
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Amarasinghe Kande Kankanamalage Dayarathna
Dinn Sean Richard
Johnson Bruce Fletcher
Rishel Michael James
Caruso Andrew J.
Chandrakumar Nizal S
General Electric Company
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