Intermediates for conjugation of polypeptides with high molecula

Details Intermediates for conjugation of polypeptides with high molecula Intermediates for conjugation of polypeptides with high molecula

1991-10-11

1994-02-01

Kulkosky, Peter F.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From heterocyclic reactant containing as ring atoms oxygen,...

548520, 424 783, 424 941, 424 7817, C07D20746, C08G 5900

Patent

active

052833178

ABSTRACT:
A biologically persistent, water-soluble, substantially non-immunogenic, substantially non-antigenic conjugate of superoxide dismutase is prepared by coupling one to five strands of a polyalkylene glycol which is polyethylene glycol or polyethylene-polypropylene glycol copolymer, wherein said polyalkylene glycol has an average molecular weight of about 35,000-1,000,000.

REFERENCES:
patent: 3337487 (1967-08-01), Nandenberg
patent: 4917888 (1990-04-01), Katre et al.
patent: 5122614 (1992-06-01), Zalipsky
Zalipsky et al. Int. J. Peptide Res. 30, 1987, 740-783.
Eur. J. Poly. vol. 19 No. 12, pp. 1177-1183, Zalipsky et al.
Journal of Chrom. 539(1991) 267-277, Birkenmeier et al.
Reactive Polymers 6(1987) 99-107, Yoshimoto et al. Jpn. J. Cancer Res. 77(1264-1270), Dec. 1980.
Richter et al. Int. Archs. Allergy Appl. Immun. 70:124-131 (1983).
Derwent Abstract, DE-4014260-A, "New Hirudin-Polyalkylene Glycol Conjugates".
Buckmann et al., "Preparation of Technical Grade Polyethylene Glycol (PEG) (M.sub.r 20,000)-N.sup.6 -(2-Aminoethyl)-NADH by a Procedure Adaptable to Large-Scale Synthesis", Biotech & App. Biochem., 1987.

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