Intermediates for benzylpyrimidines

Details Intermediates for benzylpyrimidines Intermediates for benzylpyrimidines

1985-02-27

1987-04-21

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544129, 544141, 546207, 546230, 548518, 548561, 548569, 549419, 549451, 558388, 558404, 558406, 558408, 558410, C07D29512

Patent

active

046598189

ABSTRACT:
2,4-Diamino-5-benzylpyrimidines of the formula ##STR1## wherein R.sup.1, R.sup.2, A, Z and n are as hereinafter set forth, are described. The 2,4-diamino-5-benzylpyrimidines of the invention have useful antibacterial activity. More particularly, they inhibit bacterial dihydrofolate reductase and potentiate the antibacterial activity of sulfonamides.

REFERENCES:
patent: 3513185 (1970-05-01), Cresswell et al.

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