Intermediates for antibody-vinca drug conjugates

Details Intermediates for antibody-vinca drug conjugates Intermediates for antibody-vinca drug conjugates

1988-08-08

1991-04-09

Rivers, Diana

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

530391, C07D51904, A61K 31475, A61K 3944, C07K 1528

Patent

active

050066528

ABSTRACT:
A seris of antibody-vinca drug conjugates comprise antibodies which target antigens associated with undesirable cells, so that the cells are controlled or killed by the cytotoxic vinca drug. The drug is linked to the antibody through an organic group comprising a carbonyl at the antibody end, and an alkylidene hydrazide at the vinca end.

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patent: 4675400 (1987-06-01), Cullinan
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Bumol et al., J. Cell Biochem., Supp. 9A, Abstract 0124 (1985).
Ghose et al., CRC Critical Rev. in Therapeutic Drug Carrier Systems 3, 263-359 (1987).

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