Intermediates for anti-microbial quinolone carboxylic acids

Details Intermediates for anti-microbial quinolone carboxylic acids Intermediates for anti-microbial quinolone carboxylic acids

1997-09-03

1998-09-22

Bentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560103, C07C 6306

Patent

active

058115765

ABSTRACT:
Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is cyclopropyl which may have 1 to 3 substituents of alkyl and halogen; phenyl which may be substituted by 1 to 3 substituents of alkoxy, halogen and OH; alkyl which may be substituted by halogen, alkanoyloxy or OH; alkenyl; or thienyl, R.sup.2 is 5- to 9-membered saturated or unsaturated heterocyclic ring which may be substituted, R.sup.3 is alkyl, R is H or alkyl, and X is halogen, and pharmaceutically acceptable salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.

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