Intermediates for 1,3-disubstituted 2-oxindoles as analgesic and

Details Intermediates for 1,3-disubstituted 2-oxindoles as analgesic and Intermediates for 1,3-disubstituted 2-oxindoles as analgesic and

1985-12-30

1987-04-14

Ceperley, Mary E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544333, 544405, 546256, 546269, 546270, 546273, 548127, 548134, 548181, 548236, 548247, 548248, 548431, 548450, 548454, 548468, C07D20934

Patent

active

046580379

ABSTRACT:
Certain 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position, and also on the carboxamide nitrogen atom, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic agents and anti-inflammatory agents in mammalian subjects. Certain 2-oxindole compounds unsubstituted at the 1-position but having an acyl substituent at C-3 of the formula ##STR1## and the base salts thereof, wherein X is hydrogen, 5-fluoro, 5-chloro or 5-trifluoromethyl; Y is hydrogen, 6-fluoro, 6-chloro or 6-trifluoromethyl; and R.sup.1 is benzyl, furyl, thienyl or thienylmethyl; provided that when X and Y are both hydrogen, R.sup.1 is not benzyl are useful as intermediates to the aforementioned analgesic and anti-inflammatory agents.

REFERENCES:
patent: 3462450 (1969-08-01), Shen
patent: 3519592 (1970-07-01), Holden
patent: 3631177 (1971-12-01), Holden
patent: 3634453 (1972-01-01), McManus et al.
patent: 3749731 (1973-07-01), Zinnes et al.
patent: 3856967 (1974-12-01), Allais et al.
patent: 3975531 (1976-08-01), Welstead et al.
patent: 4221716 (1980-09-01), Lo et al.
M. El-Enany et al, Bull. Faculty of Pharmacy (Cairo University), vol. 14, 29-37 (1975).
K. Buchel et al, Z. Anal. Chemie, 190, (1962), pp. 243-250.
Pakula et al., Chemical Abstracts, 72:12563(k) (1970).
Brenner et al., Chemical Abstracts, 72:12565(n) (1970).
Shen et al., Chemical Abstracts, 72:12566(p) (1970).
Wenkert et al., Journal of the American Chemical Society, 80, 4899 (1958).
Bunnett et al., Organic Syntheses, vol. 40, 1 (1960).
Capuano et al., Chemische Berichte, 105, 2539 (1972).

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