Intermediates cephalosporin derivatives

Details Intermediates cephalosporin derivatives Intermediates cephalosporin derivatives

1989-09-26

1991-11-12

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50114

Patent

active

050649531

ABSTRACT:
The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof.
The novel cephalosporin derivatives according to the present invention contain condensed heterocyclic groups, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring as substituents at the 3-position of the cephem skeleton, and a hydroxyimino, an alkyloxyimino or an acyloxyimino moiety as substituents at the 7-position of the cephem skeleton.
The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against gram-negative bacteria and also against gram-positive bacteria including methicillin-resistant Staphylococcus aureus. These compounds are extremely useful for the treatment of infectious diseases.

REFERENCES:
patent: 3907786 (1975-09-01), Maiti et al.
patent: 4098888 (1978-07-01), Ochiai
patent: 4271157 (1981-06-01), Denzel
patent: 4278793 (1981-07-01), Durkheimer et al.
patent: 4316024 (1982-02-01), Iimura et al.
patent: 4331666 (1982-05-01), Nannini et al.
patent: 4372952 (1983-02-01), Tokaya
patent: 4386210 (1983-05-01), Heymes
patent: 4436912 (1984-03-01), Wheeler
patent: 4500526 (1985-02-01), Imae et al.
patent: 4526977 (1985-07-01), Commons et al.
patent: 4547494 (1985-10-01), Oine et al.
patent: 4576938 (1986-05-01), Wagatsuma
patent: 4576956 (1986-03-01), Makisumi
patent: 4587333 (1986-05-01), Ono et al.
patent: 4594417 (1986-06-01), Yang
patent: 4600773 (1986-07-01), Engel
patent: 4604457 (1986-08-01), Torii et al.
patent: 4609654 (1986-09-01), Labeeuw et al.
patent: 4616081 (1986-10-01), Nishikido
patent: 4621081 (1986-11-01), O'Callaghan et al.
patent: 4647556 (1987-03-01), Lattrell et al.
patent: 4758556 (1988-07-01), Durckheimer et al.
patent: 4808711 (1989-02-01), Shimizu et al.
Chemical Abstract, vol. 108, No. 5, Feb. 1, 1988, p. 601, Abstract No. 37495q.
Ochiai et al, 33 J. Antibiotics, 1005-1013 (1980).
Ochiai et al, 33 J. Antibiotics, 1022-1031 (1980).
Yashida et al, 39 J. Antibiotics 215-229 (1980).
Chemical Abstracts, 966475n. (1982).
Chemical Abstracts, 99:87919x (1983).
Chemical Abstracts, 96:6477q. (1982).
Chemical Abstracts, 90:13749d, (1979).
Chemical Abstracts, 98:3442f, (1983).
Chemical Abstracts, 95:132924a, (1981).
Chemical Abstracts, 105:190724w, (1986).
Chemical Abstracts 100:174523w, (1984).
Chemical Abstracts, 104:68677x, (1986).
Chemical Abstracts, 106:101965f, (1987).
Chemical Abstracts, 88:22797j, Naito et al. (1978).
Chemical Abstracts, vol. 64, p. 5064, Undheim et al, "Semisynthetic Penicillins., IV. Preparation of (ylideniminoxy)carboxylic acids", (1966).
Naito et al., Chem. Abstracts, vol. 88 (1978), 22797.
Dunn, J. Antimicrob Chemotheraphy (1982), 10 Suppl. C pp. 1-10.
Alpegian et al., Cephalosporins VI, 36 J. Antibiotics 1013-1019 (Aug. 1983).
Chemical Abstracts 102:113169e (1985).
Chemical Abstracts, vol. 100, 1984, Abstract No. 22505d.
Chemical Abstracts, vol. 102, 1985, Abstract No. 6056u.
Chemical Abstracts, vol. 102, 1985, Abstract No. 24359z.
Chemical Abstracts, vol. 103, 1985, Abstract No. 37281p.

Affiliated with

Also associated with

Rating

Intermediates cephalosporin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Intermediates cephalosporin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intermediates cephalosporin derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1014068