Intermediate thieno-isoxazoles and -pyrazoles and 5-benzoyl-4-br

Details Intermediate thieno-isoxazoles and -pyrazoles and 5-benzoyl-4-br Intermediate thieno-isoxazoles and -pyrazoles and 5-benzoyl-4-br

1987-11-25

1988-09-06

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548370, 549 72, 549 75, C07D49804, C07D33328

Patent

active

047694726

ABSTRACT:
There are described compounds of the formula ##STR1## where X is O or NR, R being hydrogen or loweralkyl; R.sub.1 is hydrogen; and R.sub.2 is loweralkyl, arylloweralkyl, aryloxyloweralkyl or loweralkyl substituted with ##STR2## or alternatively--NR.sub.1 R.sub.2 taken together is ##STR3## R.sub.3 being arylloweralkyl or a pharmaceutically acceptable acid addition salt thereof, which are useful as ocular or systemic antihypertensive agents.
There are also described intermediate compounds having the formula ##STR4## where X is oxygen or NR, R being hydrogen or loweralkyl; and Y is --OCH.sub.3, --OH or ##STR5## as well as intermediate compounds of the formula ##STR6## where Z is oxygen, NOH or NNHR.sub.4, R.sub.4 being hydrogen or loweralkyl.

REFERENCES:
patent: 4387100 (1983-06-01), Machin
patent: 4409231 (1983-10-01), Stenzel et al.

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