Intermediate quinolin-4-ones

Details Intermediate quinolin-4-ones Intermediate quinolin-4-ones

1981-04-24

1982-05-04

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21522

Patent

active

043283420

ABSTRACT:
A process is provided for preparing pyrazolo[1,5-c]quinazoline derivatives of the structure ##STR1## wherein X is O or S; R.sup.1 is hydrogen, lower alkyl, hydroxymethyl, phenyl-lower alkyl, phenyl or phenyl substituted with halogen, lower alkyl, lower alkoxy, or trifluoromethyl; R.sup.2 is lower alkoxy, phenyl-lower alkoxy, phenoxy, or phenoxy substituted with lower alkyl or lower alkoxy; and R.sup.3 and R.sup.4 are the same or different and are selected from the group consisting of hydrogen, alkyl of 1 to 4 carbons, alkoxy of 1 to 4 carbons, lower alkanoyloxy of 1 to 4 carbons, nitro, benzyloxy, benzyloxy having a single mono-lower alkoxy substituent, halogen, hydroxy, and trifluoromethyl, wherein quinolone compounds of the structure ##STR2## which are new intermediates, are reacted with a hydrazine compound to form a 5-(2-aminophenyl)pyrazole which is then cyclized to the product.
In addition, the above product may be reacted with a halogen acid to form the corresponding hydroxymethyl compound.

REFERENCES:
patent: 3391146 (1968-07-01), Godfrey
Blechert, et al., Chemical Abstracts, vol. 78, 84,229c (1973).

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