Intermediate halophenyl derivatives and their use in a...

Details Intermediate halophenyl derivatives and their use in a... Intermediate halophenyl derivatives and their use in a...

2006-10-03

2006-10-03

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S267800

Reexamination Certificate

active

07115643

ABSTRACT:
Novel halophenyl derivatives of the general formula (I), wherein R1is halogen, a leaving group or 1H-1,2,4-triazol-1-yl and R2is ethynyl or carboxy, X1is halogen and X2and X3are each independently hydrogen or halogen, and their manufacture are described. They are intermediates for manufacturing azole derivatives of the general formula (V) which are valuable medicaments useful for treating systemic mycoses.

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An et al., Synthesis of Chiral Alkynes Having 2H or Halogen at the Secondary or Tertiary Propargylic Stereogenic Center by Hydrolysis and Halogenolysis of Optically Active Allenyltitaniums Having Axial Chirality, Tetrahedron Letters, 39(25):4555-8 (Jun. 18, 1998).
Tanaka, et al., Triazole Antifungals. V. Synthesis and Antifungal Activities of Some Amides Related to Acylamino-2-aryl-1-triazolyl-2-butanol, Chemical and Pharmaceutical Bulletin, 40(3):661-5 (1992).

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