Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1990-10-09
1994-02-15
Michl, Paul R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
C07D20508
Patent
active
052868575
ABSTRACT:
An efficient, multistep process for the synthesis of certain 6-(1-hydroxyethyl) 2-substituted penem antibiotics from 2-[4R-(triphenylmethylthio)-3S-(1R-(dimethyl-t-butylsilyloxy)ethyl)-2-azet idon-1-yl]acetic acid esters.
REFERENCES:
patent: 4272437 (1981-06-01), Menard et al.
patent: 4314942 (1982-02-01), McCombie
patent: 4443373 (1984-04-01), Girijavallabhan et al.
patent: 4443463 (1984-04-01), McCombie
patent: 4530793 (1985-07-01), Girijavallabhan et al.
patent: 4577016 (1986-03-01), Alpegiani et al.
patent: 4584133 (1986-04-01), Girijavallabhan et al.
patent: 4610823 (1986-09-01), DiNinno et al.
patent: 4614737 (1986-09-01), Hamanaka
patent: 4614738 (1986-09-01), Girijavallabhan et al.
patent: 4619924 (1986-10-01), Hamanaka
patent: 4631150 (1986-12-01), Battistini et al.
patent: 4673737 (1987-06-01), Evans et al.
patent: 4675317 (1987-06-01), DiNinno et al.
patent: 4690922 (1987-09-01), Ganguly et al.
patent: 4739047 (1988-04-01), Volkmann et al.
patent: 4751297 (1988-06-01), Cue, Jr. et al.
patent: 4769451 (1988-09-01), Dextraze
patent: 4782145 (1988-11-01), Brighty et al.
Andrus, et al., J. Am. Chem. Soc. 106, 1808-1811 (1984).
Afonso, et al., J. Am. Chem. Soc., 104, 6138-6139 (1982).
Barker, et al., Tet. Letters 28, 2283-2286 (1987).
DiNinno et al., Tet. Letters 23, 3535-3538 (1982).
Ganguly, et al., J. Antimic. Chemoth. 9 (Suppl.) C1-C5 (1982).
Ghosez, et al., Tetrahedron 39, 2493-2503 (1983).
Girijavallabhan, et al., J. Antibiot. 39, 1182-1190 (1986).
Girijavallabhan et al., Tet. Letters 24, 3179-3182 (1983).
Leanza, et al., Tetrahedron 39, 2505-2513 (1983).
Marchand-Brynaert, et al., Tet. Letters 21, 3085-3088 (1980).
Ona, et al., Chem. Pharm. Bull. 33, 4382-4394 (1985).
Perrone, et al., J. Org. Chem. 51, 3413-3420 (1986).
Franceschi, et al., J. Antibiotics 36, 938-941 (1983).
O'Neill Brian T.
Phillips Douglas
Benson Gregg C.
Brokke Mervin E.
Michl Paul R.
Pfizer Inc.
Richardson Peter C.
LandOfFree
Intermediate for the preparation of penems does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Intermediate for the preparation of penems, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intermediate for the preparation of penems will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1208375