Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-04-30
1994-10-04
Ramsuer, Robert W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
5483121, 548465, 546272, C07D20952
Patent
active
053527992
ABSTRACT:
The present invention provides processes for the synthesis of kainic acid. More specifically, the present invention is directed to a process for preparing a compound of the formula ##STR1## wherein R.sub.1 is hydrogen, acyl, alkoxycarbonyl, or arylalkoxycarbonyl;
REFERENCES:
patent: 4691022 (1987-09-01), Henning et al.
Green, T. Protective Groups in Organic Synthesis, N.Y., Wiley & sons, 1981, pp. 224-225, 239.
Oppolzer and Andres, "A Total Synthesis of .alpha.-Kainic Acid by an Intramolecular Ene Reaction", Helv. Chim. Acta, 62, 2282 (1979).
Potts, Choudhury, and Westby, "Bridgehead Nitrogen Systems.X. Cycloadditions with Thiazolium N-Ylides.sup.1 ", J. Org. Chem., 41, 187 (1976).
Kraus and Nagy, "The synthesis of amino acids by 1,3-dipolar cycloadditions of azomethine ylides", 41, 3537 (1985).
Reetz, Kyung, and Hullman, "CH.sub.3 Li/TiCl.sub.4 : A non-basic and highly selective grignard analogue", Tetrahedron, 42, 2931 (1985).
Carlsen, Katsuki, Martin, and Sharpless, "A Greatly Improved Procedure for Ruthenium Tetraoxide Catalyzed Oxidations of Organic Compounds", J. Org. Chem., 46, 3936 (1981).
Hibino, Okazoe, Takai, and Nozaki, "Carbonyl methylenation of easily enolizable ketones", Tetr. Lett., 26, 5579 (1985).
Takano, Sugihara, Satoh, and Ogasawara, "Enantioselective Synthesis of (-)-Kainic Acid", J. Am. Chem. Soc., 110, 6467 (1988).
Husinec, Porter, Roberts, and Strachan, "Some Approaches to the Synthesis of Kainic Acid", J. Chem. Soc., Perkin Trans. I, 2517 (1984).
Husinec, Porter, and Strachan, "Approaches to the synthesis of kainic acid. A Study of the synthesis of some 4,5-dihydro-1,2,3-triazoles", Coll. Czech. Chem. Comm., 52, 207 (1987).
Murakami, Hasegawa, Hayashi, and Ito, "Synthesis of (+)-a-Allokainic Acid via the Zinc Acetate Catalyzed Cyclization of .gamma.-Isocyano Silyl Enolates", J. Org. Chem., 56, 7356 (1991).
Takano, Inomata, and Ogasawara, "A New Enantiospecific Route to (-)-Kainic Acid via the Intramolecular Pauson-Khand Reaction", J. Chem. Soc. Chem. Comm., 169 (1992).
Eli Lilly and Company
Haley Jacqueline
Leeds James P.
Ramsuer Robert W.
LandOfFree
Intermediate compounds useful in the synthesis of kainic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Intermediate compounds useful in the synthesis of kainic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intermediate compounds useful in the synthesis of kainic acid will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-582540