Intermediate compounds useful for making HIV protease inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07C 69003

Patent

active

059627255

ABSTRACT:
HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive compounds and intermediates.

REFERENCES:
patent: 5063208 (1991-11-01), Rosenberg et al.
patent: 5142056 (1992-08-01), Kempe et al.
patent: 5157041 (1992-10-01), Handa et al.
patent: 5196438 (1993-03-01), Martin et al.
patent: 5204471 (1993-04-01), Negele et al.
patent: 5235039 (1993-08-01), Heath, Jr. et al.
patent: 5256783 (1993-10-01), Gokhale et al.
patent: 5434265 (1995-07-01), Fritz et al.
patent: 5463104 (1995-10-01), Vasquez et al.
patent: 5484926 (1996-01-01), Dressman et al.
patent: 5514802 (1996-05-01), Fritz et al.
patent: 5527829 (1996-06-01), Kalish
patent: 5705647 (1998-01-01), Babu et al.
Tam et al., J. Med. Chem., 35(7):1318-1320 (1992).
Huff, J. Med. Chem., 34(8):2305-2314 (1991).
Ghosh et al., J. Med. Chem., 36(2):292-294 (1993).
Ghosh et al., J. Med. Chem., 36(16):2300-2310 (1993).
Thompson et al., J. Am. Chem. Soc., 115(2):801-802 (1993).
Rich et al., J. Med. Chem., 34(3):1222-1225 (1991).
Thaisrivongs et al., J. Med. Chem., 34(8):2344-2356 (1991).
Ghosh et al., J. Med. Chem., 36(7):924-927 (1993).
Chong et al., J. Med. Chem., 36:2575-2577 (1993).
Prasad et al., Peptides, Chemistry and Biology, Proceedings of the Twelfh American Peptide Symposium, pp. 721-722 (1991).
Rich et al., Chem. Abstracts, 114(15) Abstract No. 143998g (1991).
Houpis et al., Tetrahyedron Letters, 34(16):2593-2596 (1993).
Roberts, et al., Science, 248:358-361 (1990).
Gilbert et al., J. Chem. Soc. Perkin Trans., 2:475-479 (1993).
Young et al., J. Med. Chem., 35(10):1702-1709 (1992).
Lyle et al., J. Med. Chem., 34(3):1228-1230 (1993).
Peltier et al., "Contribution a l'etude du groupe carboxylique. Absorption infrarouge et ionisation," Bulletin de la Societe chimique de France, (1960), 1141-1147.
Mukharji et al., Indian J. Chem., EN, 9, (1971), 515-523, as abstracted in Database Xfire> Beilstien, 3-methoxy-2-methyl-benzoic acid ethyl ester.
Ratner et al., Complete nucleotide dequence of the AIDS virus, HTLV-III, Nature, vol. 313, Jan. 24,1985.
Rose et al., "Regulation of Autoproteolysis of the HIV-1 and HIV-2 Proteases with Engineered Amino Acid Substitutions", Journal of Biological Chemistry, vol. 268, No. 16, pp. 11939-11945 (1993).
Menge et al., "Structure-Function Analysis of the Mammalian DNA Polymerase Active Site: role of Aspartic Acid 256, Arginine 254, and Arginine 258 in Nucleotidyl Transfer", Biochemistry 1995, 34, 19934-15942.
Celis et al., "Chain-terminating Mutants Affecting a Periplasmic Binding Protein Involved in the Active Transport of Arginine and Ornithine in Escherichia coli", Journal of Biological Chemistry, vol. 256, No. 2, pp. 773-779, 1981.
Morrison, Lometocs pf tje reversob;e Omjobotopm pf Emzu, e-Catalysed Reactions by Tight-Binding Inhibitors, Biochim. Biophys. Acta, 185 (1969) 269-286.
Alley, et al., "Feasibility of Drug Screening with Panels of Human Tumor Cell Lines using a Microculture Tetrazolium Assay", Cancer Research, 48, 589-601, Feb. 1, 1988.
J. Townsend, et al., "Novel Copper Complexes of Chiral Diphosphines: Preparation, Structure and Use to Form Rhodium Complex Catalysts for Chiral Hydrogenations", J. Org. Chem., 1980, 45, pp. 2995-2999.
Mash et al., "1,4 Di-o-alkly Threitols from Tartaric Acid", Org. Synthesis, Coll. vol. VIII, pp. 155-161. 1980.
S. Takano, et al., "Selective Manipulation of Hydroxy Groups in (2S,3S)-Threitol", Synthesis, Oct. 1986, pp. 811-817.
T. Ozturk, et al., "Synthesis of a Chiral Monosubstituted Derivative of Bis(ethylenedithio)tetrathiafulvalene: Reaction of the cyclic Sulfate Ester of R,R-1-Difluorobutane-2,3-diol ith 2-Thioxo-1,3-dithiole-4,5-dithiolate", J. Mater. Chem., 1995, 5(10), 1553-1556.
K. Vanhessche et al., "Catalytic Asymmetric Synthesis of Ne Halogenated Chiral Synthons", Chem. Eur. J. 1997, 3. No. 4.
Gao et al., "Vicinal Diol Cyclic Sulfates: Like Epoxides Only More Reactive", J. Am. Chem. Soc. 1988, 110, 7538-7539.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Intermediate compounds useful for making HIV protease inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Intermediate compounds useful for making HIV protease inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intermediate compounds useful for making HIV protease inhibitors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1173488

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.