Intermediate compounds of non-nucleoside reverse...

Details Intermediate compounds of non-nucleoside reverse... Intermediate compounds of non-nucleoside reverse...

2005-05-17

2005-05-17

Rao, Deepak (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S026000, C549S043000

Reexamination Certificate

active

06894177

ABSTRACT:
Compounds of the formula I:where;R1is O, S;R2is an optionally substituted nitrogen-containing heterocycle, wherein the nitrogen is located at the 2 position relative to the (thio)urea bond;R3is H, C1-C3alkyl,R4-R7are independently selected from H, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, haloC1-C6alkyl, C1-C6alkanoyl, haloC1-C6alkanoyl, C1-C6alkoxy, haloC1-C6alkoxy, C1-C6alkyloxy-C1-C6alkyl, haloC1-C6alkyloxy-C1-C6alkyl hydroxy-C1-C6alkyl, amino-C1-C6alkyl, carboxy-C1-C6alkyl, cyano-C1-C6alkyl, amino, carboxy, carbamoyl, cyano, halo, hydroxy, keto;X is —(CH2)n−—D—(CH2)m—;D is —O—, —S—;n and m are independently 0 or 1;and prodrugs and pharmaceutically acceptable salts thereof, have utility as inhibitors of HIV-1 reverse transcriptase, particularly drug escape mutants.

REFERENCES:
patent: 3803175 (1974-04-01), Sparks et al.
patent: 2041563 (1971-03-01), None
patent: Wo 9303022 (1993-02-01), None
patent: WO 9506034 (1995-03-01), None
patent: WO 9936406 (1999-07-01), None
patent: WO 9947501 (1999-09-01), None
patent: WO 0039095 (2000-07-01), None
patent: WO 0047561 (2000-08-01), None
patent: WO 0056736 (2000-09-01), None
patent: WO 0078315 (2000-12-01), None
patent: WO 0078721 (2000-12-01), None
patent: WO 0078755 (2000-12-01), None
patent: WO 0078756 (2000-12-01), None
Badger et al., CAOLD Abstract 52:17228c, 1959.*
Chatterjee et al., CAOLD Abstract 79:66064, 1973.*
Chatterjee et al., Mechanism, Stereoselectivity and Generality of a Novel Cyclopropane Formation, Tetrahedron Letters, No. 19, pp. 1683-1686,1973.*
Derrick L. J. Clive et al., “Synthesis of (±)-puraquinonic acid: an inducer of cell . . . ,” J. Org. Chem. 2001, 66, pp. 954-961. XP-002216804.
M.G. Kulkarni et al., “Synthesis of novel 3-allylbenzofurans via . . . ,” Synthesis. 1997, 12, pp. 1420-1424. XP-001106509.
Biswajit Saha et al., “Intramolecular asymmetric cyclopropanation . . . ,” Synlett. 2001, 1(1), pp. 114-116. XP-001106507.
Chi-Ming Che et al., “Asymmetric inter- and intramolecular cyclopropanation . . . ,” J. Am. Chem. Soc. 2001, 123, pp. 4119-4129. XP-002216805.
Masakatsu Masumoto et al., “o-Benzochinon-monoformylmethide durch . . . ,” Angew. Chem. 1982, 94 (5), pp. 376-377. XP002216806.
Andre Rosowsky et al., “2,4-Diaminothiene [2,3-d] pyrimidine analogue . . . ,” J. Med. Chem. 1993, 36, pp. 3103-3112. XP-001106506.
Manik S. Sardessai et al., “The bromination of 2,5-dimethoyxbenzaldehyde . . . ,” Organic Preparations and Procedures Int. 1991, 23 (4), pp. 419-424. XP-002216807.
Takao Sakamoto et al., “Condensed heteroaromatic ring systems . . . ,” Tetrahedron, 1991, 47 (10), pp. 1877-1886. XP001106510.
Stephen F. Martin et al., “Iodocyclopropanes as Versatile Intermediates . . . ,” Tetrahedron Letters, 1998, 39, pp. 1521-1524. XP002216808.
Tatsuya Uchida et al., “Co(II)-salen-catalyzed asymmetric intramolecular cyclopropanation . . . ,” Tetrahedron Letters, 2001, 42, pp. 2521-2524. XP-002216809.
Yuki Takekawa et al., “Selective cleavage of the trisubstituted . . . ,” Tetrahedron Letters, 1999, 40, pp. 6817-6820. XP-002216810.
Eric L. Dias et al., “Rhodium (I)-Catalyzed homologation of aromatic . . . ,” J. Am. Chem. Soc. 2001, 123, pp. 2442-2443. XP002216811.
Robert S. Coleman et al., “A covergent approach to the . . . ,” Organic Letter, 2001, 3 (8), pp. 1141-1144. XP002216812.
Leticia Perez-Serrano et al., “Synthesis of tricyclic aromatic compounds by the . . . ,” J. Org. Chem. 2000, 65, pp. 3513-3519. XP-002216813.
Gregory H. Merriman et al.,“The Synthesis of N-(Pyridylamino) tetrahydroisoquinolines and . . . ,” Synlett, 2000, 1, pp. 137-0139. XP001106583.
Arun K. Jain et al., “Some new constituents from . . . ,” J. Indian Chem. Soc., Aug. 1991, pp. 452-454. XP-002216814.
Reckendorf, W. Meyer eta l.; “Synthesis of Methyl 4, 6-O-Benzylidene-2, 3 . . .” Angew. Chem. Internat. Edit. vol. 7 (1968) No. 2.
Reckendorf, W. Meyer et al.; “Synthesis von 2.3-[2-Amino-athyliden] . . .” Chem. Ber. 105, 686-695 (1972).
Hogberg, Marita et al.; “Urea-PETT Compounds as a New Class . . .” J. Med. Chem. 1999, 42, 4150-4160.
Cantrell, Amanda S. et al.; “Phenethylthiazolythiourea (PETT) Compounds . . .” J. Med. Chem. 199, 39, 4261-4274.
Bell, Frank W. et al.; “Phenethylthiazolethiourea (PETT) Compounds, a New Class of . . .” Reprinted from Journal of Medical Chemistry, 1995, 38, pp. 4929-4936.
Kirmase, Wolgang et al.; “Carbenes and the O-H Bond; . .” J. Org. Chem. 1988, 53, 763-767.

Affiliated with

Also associated with

Rating

Intermediate compounds of non-nucleoside reverse... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Intermediate compounds of non-nucleoside reverse..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intermediate compounds of non-nucleoside reverse... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3383830