Intermediate compounds for the preparation of trans...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S410000

Reexamination Certificate

active

07872147

ABSTRACT:
Disclosed are novel amino acid derivatives of formula (I) and (II)processes for the preparation thereof, and their use in the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino-[4,5-c]pyrrole.

REFERENCES:
patent: 4145434 (1979-03-01), van der Burg
patent: 49069697 (1974-07-01), None
patent: WO 95/23600 (1995-09-01), None
patent: WO 99/32108 (1999-07-01), None
Vader et al. (J. Labelled Comp. Radiopharm., 34, 845-869 (1994)), cited in IDS.
Mar. (March;s Advanced Organic Chemistry, 5th ed., Eds. Smith and March, chapter 16 provided, 2001).
De Boer, Th. et al., Org-5222 “Antipsychotic Dopamine D2Receptor Antagonist 5-HT2Receptor Antagonist,” Drugs of the Future, vol. 18, No. 12 (1993) pp. 1117-1123.
Funke, C. W. et al., “Physico-chemical Properties and Stability of trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrolidine Maleate,” Arzneim.-Forsch./Drug Res., vol. 40, No. 5 (1990) pp. 536-539.
Vader, J. et al. “The Syntheses of Radiolabelled Org 5222 and its Main Metabolite Org 30526,” Journal of Labelled Compounds and Radiopharm., vol. 34, No. 9 (1994), pp. 845-869.
European Search Report for Application No. EP 06 11 2333 dated May 29, 2006.

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