Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2007-09-04
2007-09-04
Bernhardt, Emily (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C564S155000
Reexamination Certificate
active
10488909
ABSTRACT:
The present invention is directed to intermediate compounds of mirtazapine and methods for obtaining same. A method is described for obtaining (±)-3-phenyl-1-methylpiperazine, an important intermediate for obtaining mirtazapine, which is based on imposing a cyclization reaction, in the presence of a reducing agent, on new compounds of general formula (1)in which Z is a leaving group capable of undergoing a nucleophilic displacement. A method is also described for obtaining the new compounds of formula (1).
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patent: 5681962 (1997-10-01), Callander
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patent: WO 00/63185 (2000-10-01), None
Van Der Burg, W.J.,J. Med. Chem, vol. 132, No. 1 (1970) pp. 35-39.
Bosch i Lladó Jordi
Camps García Pelayo
Contreras Lascorz Juan
Miguel Ma Carmen Onrubia
Bernhardt Emily
Medichem S.A.
Scully , Scott, Murphy & Presser, P.C.
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