Intermediate compound for synthesis of viridiofungin a...

Details Intermediate compound for synthesis of viridiofungin a... Intermediate compound for synthesis of viridiofungin a...

2010-02-04

2011-10-04

Kosar, Andrew D (Department: 1622)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

08030496

ABSTRACT:
A method whereby a compound having HCV replication inhibitory activity and desired optical activity can be synthesized selectively and at high yield in a small number of steps by using a compound having a specific chiral auxiliary as a starting compound is provided.A compound represented by the formula (1-8):wherein Y represents a group represented by the following formula:Q represents a protected carbonyl group; D represents —(CH2)m—R′, etc.; and n represents an integer of 0 to 10.

REFERENCES:
patent: 5498719 (1996-03-01), Marquez et al.
patent: 6303350 (2001-10-01), Takesako et al.
patent: 2006/0194870 (2006-08-01), Sudoh et al.
patent: 2006/0217434 (2006-09-01), Aoki et al.
patent: 9-143173 (1997-06-01), None
patent: WO 98/56755 (1998-12-01), None
patent: WO 2004/071503 (2004-08-01), None
patent: WO 2005/005372 (2005-01-01), None
Bates et al., “Dianions of glyoxylic acid thioketals: convenient α-keto acid equivalents,” Can. J. Chem., 1980, 58:716-722.
DuBois et al., “Observations on theChemistry of alpha-Azido Esters. Efficient Synthesis of a Potently Sweet Homoserine-Dihydrochalcone Conjugate,” J. Org. Chem., 1982, 47(7):1319-1323.
Gollnick et al., “Dye-Sensitized Photooxygenation of 2,3-Dihydrofurans: Competing {2+2} Cycloadditions and Ene Reactions of Singlet Oxygen with a Rigid Cyclic Enol Ether System,” J. Org. Chem., 1991, 56(12):4017-4027.
Guz et al., “Practical and Highly Selective Oxazolidinethione-Based Asymmetric Acetate Aldol Reactions with Aliphatic Aldehydes,” Organic Letters, 2002, 4(13):2253-2256.
Hilbert et al., “Base-Catalyzed Beta-Elimination Reactions. 7. Elimination from 4-(Para-substituted-phenoxy)-2-oxobutanoic Acids,” J. Org. Chem., 1978, 43(3):452-459.
Hirai et al., “Totally Synthesis of (±)-Trachyspic Acid and Determination of the Relative Configuration,” Organic Letters, 2003, 5(6):857-859.
Myers et al., “Use of Pseudoephedrine as Practical Chiral Auxiliary for Asymmetric Synthesis,” J. Am. Chem. Soc., 1994, 116:9361-9362.
Palomo et al., “Highly Diastereoselective Aldol Reactions with Camphor-Based Acetate Enolate Equivalents,” J. Org. Chem., 1999, 64:8193-8200.
Radosevich et al., “Vanadium-Catalyzed Asymmetric Oxidation of alpha-Hydroxy Esters Using Molecular Oxygen as Stoichiometric Oxidant,” J. Am. Chem. Soc., 2005, 127(4):1090-1091.
Sheldon et al., “Green, Catalytic Oxidations of Alcohols,” Acc. Chem. Res., 2002, 35:774-781.
Tavecchia et al., “Degradation Studies of Antibiotic MDL 62,879 (GE2270A) and Revision of the Structure,” Tetrahedron, 1995, 51(16):4867-4890.

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