Intermediate and process of preparation of ecteinascidin...

Details Intermediate and process of preparation of ecteinascidin... Intermediate and process of preparation of ecteinascidin...

2006-10-20

2011-11-15

Wilson, James O (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

active

08058435

ABSTRACT:
The present invention concerns an intermediate of the following formula (I) in which R1and R2represent independently of each other a C1-C12alkyl group, a (C1-C12alkoxy)carbonyl group, optionally substituted by one, two or three halogen atom, a (C2-C12alkenyloxy)carbonyl group, an acyl group, a aryl(C1-C12)alkyl group, an arylalkoxy carbonyl group, a (C1-C12alkyl)sulfonyl group or an arylsulfonyl group, R3represents a O-protecting group, R4and R5represent independently of each other a hydrogen atom or a O-protecting group, R6represent a O-protecting group and R7represent a C1-C12alkyl group or —OR6and —OR7form together a group —OCH2O—. The present invention concerns also a process of preparation of the intermediate and its use for the preparation of Ecteinascidin 743 and Ecteinascidin-770.

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