Intermediate and process for preparing of β- anomer...

Details Intermediate and process for preparing of β- anomer... Intermediate and process for preparing of β- anomer...

2007-06-26

2007-06-26

Crane, L. E. (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S063000, C536S028500, C536S055300

Reexamination Certificate

active

11332830

ABSTRACT:
The present invention provides a highly stereoselective, simple and economical glycosylation process for preparation of β-anomer enriched 21-deoxy-21,21-D-ribofuranosyl difluoronucleosides of formula (II), and physiologically acceptable slats thereof, in particular, the β-enriched anomer of gemcitabine hydrochloride of formula (IIb) in purity of >99% is provided through utilization of a novel trichloroacetimidate of formula (I).

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