Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1990-11-08
1993-02-23
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
514 8, 514 12, 530351, A61K 4505, C07K 1300
Patent
active
051888289
ABSTRACT:
The invention is directed to the administration of Interleukin 6 for the purpose of enhancing endogenous erythropoietin levels in vitro and in vivo. The invention further encompasses methods of treatment of disorders characterized by, or including, erythropoietin deficiency. Such disorders include the anemias of chronic inflammation, renal failure, AIDS, and malignancy.
REFERENCES:
Miller et al. (Jun. 1990) New Engl. J. Med. 322(24):1689-1692.
Doweiko et al. (1991) Oncology 5(8):31-37.
Schuster et al. (1992) Br. J. Hematology 81:153-159.
Fried, W. (1972) Blood 40(5):671-677.
Tan et al. (1991) Kidney Int. 40:69-76.
Goldberg (1990) "Erythropoietin in Clinical Applications", Marcel Dekker, Inc., New York, pp. 59-104.
Bondurant et al. (1986) Mol. Cell. Biol. 6(7):2731-2733.
Moore et al. (1986) "Delivery Systems for Peptide Drugs", Plenum Press, N.Y., pp. 317-329.
Ishibashi et al. (Sep. 1989) Blood 74(4):1241-1244.
Gardner et al. (Jun. 1, 1990) Blood 75(11):2150-2155.
Geiger et al. (1988) Eur. J. Immunol. 18:717-721.
Takatsuki et al. (1988) J. Immunol. 141(9):3072-3077.
Bot et al. (1989) Blood 73(2):435-437.
Rennick et al. (1989) Blood 73(7):1828-1835.
Faquin et al. (1992) Blood 79(8):1987-1994.
Kitahara et al. (Oct. 1990) Jpn. J. Cancer Res. 81(10):1032-1038.
Mule et al. (Mar. 1, 1990) J. Exp. Med. 171(3):629-636.
Goldberg et al. (1988) Science 242:1412-1415.
Brakenhoff et al. (Aug. 15, 1989), J. Immunology 143(4):1175-1182.
Goldberg et al. (1987), Proc. Natl. Acad. Sci. U.S.A. 84:7972-7976.
Baumann et al. (Nov. 25, 1988) J. Biol. Chem. 263(33):17390-17396.
Ulich et al. (Jan. 1989), Blood 73(1):108-110.
Faquin William C.
Goldberg Mark A.
Brigham and Women's Hospital
Ekstrom Richard C.
Wax Robert A.
LandOfFree
Interleukin-6 to stimulate erythropoietin production does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Interleukin-6 to stimulate erythropoietin production, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Interleukin-6 to stimulate erythropoietin production will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2203164