Interleukin-6 splice variant

Details Interleukin-6 splice variant Interleukin-6 splice variant

1996-12-13

1999-09-28

Mertz, Prema

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

530351, 435 6952, 435 711, 435 712, 435325, 4352523, 4353201, 435471, 536 231, 536 235, A61K 3820, C07K 1454, C12N 1524, C12N 1563

Patent

active

059584009

ABSTRACT:
Polynucleotides which encode the polypeptide IL-6SV, as well as such polypeptides, antibodies and antagonist inhibitors against the polypeptide and the use of the polypeptide as a pharmaceutical for treating cancer, auto-immune diseases, platelet reducing conditions, anemias, bone marrow and organ transplantation.

REFERENCES:
patent: 5641657 (1997-06-01), Ruben et al.
Yasukawa et al., The EMBO Journal, vol. 6: 2939-2944 (1987).
Haegeman et al., Eur. J. Biochem., vol.159:625-632 (1986).
Hirano et al., Letters to Nature, vol. 324:73-76 (1986).
Zilberstein et al., The EMBO Journal, vol. 5:2529-2537 (1986).
Cunningham et al. (1989) Science vol. 244, pp. 1081-1085.
George et al. (1988) Macromolecular Sequencing & Synthesis Alan R. Liss, Inc. New York, pp. 127-149.

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