Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1995-12-04
1998-08-04
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
435 6952, 435325, 4352523, 4353201, 930140, C07K 1454, C12N 1524, C12N 1563, C12N 510
Patent
active
057895520
ABSTRACT:
Disclosed are interleukin-6 receptor antagonists. These receptor antagonists are generated by mutating amino acid positions 31, 35, 118, 121, 175, 176 and/or 183 of human interleukin-6.
REFERENCES:
patent: 5132403 (1992-07-01), Kishimoto
patent: 5210075 (1993-05-01), Scholz et al.
patent: 5506107 (1996-04-01), Cunningham et al.
Rudinger, J. 1976. Characteristics of the amino acids as components of apide hormone sequence. In: Parsons JA, ed. Peptide hormones. Baltimore, Univ Park Press. pp. 1-7, 1976.
Cillberto Gennaro
Lahm Armin
Savino Rocco
Istituto di Ricerche di Biologica Molecolare P. Angeletti S.p.A.
Saoud Christine
Ulm John
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