Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1995-12-04
1999-04-06
Olm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
435 6952, 435325, 4352523, 4353201, 930140, C07K 1454, C12N 1524, C12N 1563, C12N 510
Patent
active
058919988
ABSTRACT:
Disclosed are interleukin-6 receptor agonists. These receptor agonists were enerated by mutating amino acid positions 175, 176, 177, 181, and/or 183 of human interleukin-6.
REFERENCES:
patent: 5506107 (1996-04-01), Cunningham et al.
Savino et al. Proc. Natl. Acad. Sci 90:4067-4071 May 1993.
Ciliberto Gennaro
Lahm Armin
Savino Rocco
Istituto di Ricerche di Biologica Molecolare P. Angeletti S.p.A.
Olm John
Saoud Christine
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