Interleukin-5 specific recombinant antibodies

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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5303881, 53038823, 4241331, 4241451, 435 696, 435 697, 435328, 435335, A61K 39395, C07K 1626, C12N 1513

Patent

active

059985860

ABSTRACT:
An effective anti-IL-5 recombinant antibody molecule comprising heavy and/or light chain antigen-binding residues from a donor antibody.

REFERENCES:
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Cockett, et al., Nucl. Acids Res., 19, 319-325 (1991).
Jones, P. et al., "Replacing the complementarity-determining regions in a human antibody with those from a mouse", Nature, 321, 522-525, (1986).
Maniatis, et al., Molecular Cloning: A Laboratory Manual, Second Edition, vols. 1-3, Cold Spring Harbor Laboratory Press (1989).
Queen, et al., "A humanized antibody that binds to the interleukin 2 receptor", Proc. Natl. Acad. Sci. USA, 86, 10029-10033 (1989).
Riechmann, et al., "Reshaping human antibodies for therapy", Nature, 332, 323-327 (1988).
Verhoeyen, et al., Science, 239, 1534-1536 (1988).
Rudikoff et al Proc Natl Acad Sci USA vol. 79:1979, 1982.

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