Interleukin-2/viral antigen protein chimers

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.

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435 6952, 435 697, 530395, 530403, 536 234, A61K 3820, C07K 1455, C12N 1562

Patent

active

055569463

ABSTRACT:
Disclosed are (1) a fused protein obtained by combining an antigen used for vaccine and a lymphokine by the application of gene engineering, (2) a recombinant DNA containing a nucleotide sequence coding for the above fused protein, (3) a transformant bearing the above recombinant DNA, (4) a method for producing the fused protein which comprises cultivating the above transformant, producing and accumulating the above fused protein in a culture, and collecting the fused protein, and (5) a hybrid protein obtained by chemically combining an antigen used for vaccine with a lymphokine. The resulting fused and hybrid proteins have strong immunogenicity.

REFERENCES:
Weinberg et al., Journal of Immunology, 140:1, pp. 294-299 (1988).
R. Seno et al., FEBS, 199:2, pp. 187-192 (1986).

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