Interleukin-2 stimulated T lymphocyte cell death for the treatme

Details Interleukin-2 stimulated T lymphocyte cell death for the treatme Interleukin-2 stimulated T lymphocyte cell death for the treatme

1995-06-07

1999-11-23

Minnifield, Nita

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

4241541, 4241431, 4241441, 424 851, 424 852, 514 12, 514 2, 514885, A61K 3900, A61K 39395, A61K 4505, A61K 3800

Patent

active

059895462

ABSTRACT:
A method for the treatment or prevention of allergic disorders is provided, comprising inducing the death by apoptosis of a subpopulation of T lymphocytes that is capable of causing such diseases, while leaving substantially unaffected the majority of other T lymphocytes. Cell death is achieved by cycle(s) comprising challenging via immunization these T cells with antigenic substance at short time intervals, or by immunization followed by administering interleukin-2 (IL-2) when these T cells are expressing high levels of IL-2 receptor so as to cause these T cells to undergo apoptosis upon re-immunization with the antigenic peptide or protein. These methods are applicable to the treatment of allergic disorders such as hay fever, extrinsic asthma, or insect bite and sting allergies, and food and drug allergies.

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