Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Patent
1996-12-03
1998-09-15
LeGuyader, John L.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
435 6, 435 9131, 4351723, 4353201, 435325, 536 231, 536 232, 536 245, C07H 2109, C12Q 168, C12N 1585
Patent
active
058077430
ABSTRACT:
A nucleic acid molecule which blocks synthesis and/or expression of an IL-2R encoded RNA, wherein said nucleic acid molecule is used to treat graft rejection, an autoimmune disease, cancer, psoriasis, an allergy or other inflammatory disease.
REFERENCES:
patent: 4987071 (1991-01-01), Cech et al.
patent: 5135917 (1992-08-01), Burch
patent: 5334711 (1994-08-01), Sproat et al.
patent: 5359051 (1994-10-01), Cook et al.
patent: 5525468 (1996-06-01), McSwiggen
Arima et al., J. Exp. Med. 176:1265 (1992).
Caine, "Immunosuppression for Organ Grafting," Transplantation Proceedings 24:1260-1262 (1992).
Campen et al., Arthritis Rheum 31:1358 (1988).
Carlson et al., "Effects of Orally Administered Rapamycin in Animal Models of Arthritis and Other Autoimmune Diseases," in Immunomodulating Drugs: Annals of the New York Academy of Sciences 685:86-113 (1993).
Carter, "Adeno-Associated Virus Vectors," Curr Opi. Biotech. 3:533-539 (1992).
Chen et al., "Multitarget-Ribozyme Directed to Cleave at up to Nine Highly Conserved HIV-1 env RNA Regions Inhibits HIV-1 Replication-Potential Effectiveness Against Most Presently Sequenced HIV-1 Isolates," Nucleic Acids Research 20:4581-4589 (1992).
Chowrira and Burke, "Extensive Phosphorothioate Substitution Yields Highly Active and Nuclease-Resisant Hairpin Ribozymes," Nucleic Acids Research 20:2835-2840 (1992).
Chowrira et al., "In Vitro and in Vivo Comparison of Hammerhead, Hairpin, and Hepatitis Delta Virus Self-Processing Ribozyme Cassettes," J. Biol. Chem. 269:25856-25864 (1994).
Collins and Olive, "Reaction Conditions and Kinetics of Self-Cleavage of a Ribozyme Derived From Neurospora VS RNA," Biochemistry 32:2795-2799 (1993).
Dropulic et al., "Functional Characterization of a U5 Ribozyme: Intracellular Suppression of Human Immunodeficiency Virus Type I Expression," Journal of Virology 66:1432-1441 (1992).
Duval-Valentin, "Specific inhibition of transcription by triple helix-forming oligonucleotides," Proc. Natl. Acad. Sci. USA 89:504-508 (1992).
Egholm et al., "PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules," Nature 365:566-568 (1993).
Elroy-Stein and Moss, "Cytoplasmic Expression System Based on Constitutive Synthesis of Bacteriophage T7 RNA Polymerase in Mammalian Cells," Proc. Natl. Acad. Sci. USA 87:6743-6747 (1990).
Feldstein et al., "Two sequences participating in the autolytic processing of satellite tobacco ringspot virus complementary RNA," Gene 82:53-61 (1989).
Finck et al., "Treatment of Murine Lupus with CTLA41g," Science 265:1225-1227 (1994).
Fodor et al., "Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogenic hyperacute organ rejection," Proc. Natl. Acad. Sci. USA 91:11153-11157 (1994).
Forster and Altman, "External Guide Sequences for an RNA Enzyme," Science 249:783-786 (1990).
Fulehian et al., "Cyclosporin A Inhibits CD40 Ligand Expression in T Lymphocytes," J. Clin. Invest. 93:1315-1320 (1994).
Gao and Huang, "Cytoplasmic Expression of a Reporter Gene by Co-Delivery of T7 RNA Polymerase and T7 Promoter Sequence with Cationic Liposomes," Nucleic Acids Research 21:2867-2872 (1993).
Gottlieb et al., Nature Medicine 1:442 (1995)2.
Griffin et al., "Group II intron ribozymes that cleave DNA and RNA linkages with similar efficiency, and lack contacts with substrate 2'-hydroxyl groups," Chemistry & Biology, 2:761-770 (1995).
Guerrier-Takada et al., "The RNA Moiety of Ribonuclease P Is the Catalytic Subunit of the Enzyme," Cell 35:849-857 (1983).
Guo and Collins, "Efficent trans-cleavage of stem-loop RNA substrate by a ribozyme derived from Neurospora VS RNA," EMBO J. 14:368-376 (1995).
Hampel et al., "`Hairpin` Catalytic RNA Model: Evidence for Helices and Sequence Requirement for Substrate RNA," Nucleic Acids Research 18:299-304 (1990).
Hampel and Tritz, "RNA Catalytic Properties of the Minimum (-)s TRSV Sequence," Biochemistry 28:4929-4933 (1989).
Haseloff and Gerlach, "Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities," Nature 334:585-591 (1988).
Haseloff and Gerlach, "Sequences required for self-catalysed cleavage of the satellite RNA of tobacco ringspot virus," Gene 82:43-52 (1989).
Hatakeyama et al., Science 244:551 (1989).
Hertel et al., "Numbering System for the Hammerhead," Nucleic Acids Research 20:3252 (1992).
Izant and Weintraub, "Constitutive and Conditional Suppression of Exogenous and Endogeneous Genes by Anti-Sense RNA," Science 229:345-352 (1985).
Jaeger et al., "Improved Predictions of Secondary Structures for RNA," Proc. Natl. Acad. Sci. USA 86:7706-7710 (1989).
Jeffries and Symons, "A Catalytic 13-mer Ribozyme," Nucleic Acids Research 17:1371-1377 (1989).
Kashani-Sabet et al., "Reversal of the Malignant Phenotype by an Anti-ras Ribozyme," Antisense Research & Development 2:3-15 (1992).
Kelly et al., J. Immunol. 140:59 (1988).
Kemeny and Diaz-Sanchez, "Can persistent IgE responses be suppressed?" Clin. Exp. Immunol. 82:423-426 (1990).
Keystone et al., Arthritis Rheum 31:844 (1988).
Kondo et al., Science 262:1874 (1993).
Kuus-Reichel et al., Hybridoma 13:115 (1994).
L'Huillier et al., "Cytoplasmic Delivery of Ribozymes Lead to Efficient Reduction in .alpha.-Lactalbumin mRNA Levels in C1271 Mouse," Embo J. 11:4411-4418 (1992).
Leonard et al., Nature 311:626 (1984).
Li and Altman, "Cleavage by RNase P of gene N mRNA reduce bacteriophage .lambda. burst size," Nucleic Acids Research 24:835-842 (1996).
Lieber et al., "Stable High-Level Gene Expression in Mammalian Cells by T7 Phage RNA Polymerase," Methods Enzymol. 217:47-66 (1993).
Lisziewicz et al., "Inhibition of Human Immunodeficiency Virus Type 1 Replication by Regulated Expression of a Polymeric Tat Activation Response RNA Decoy as a Strategy for Gene Therapy in AIDS," Proc. Natl. Acad. Sci. U.S.A 90:8000-8004 (1993).
McGarry and Lindquist, "Inhibition of heat shock protein synthesis by heat-inducible antisense RNA," Proc. Natl. Acad. Sci. USA 83:399-403 (1986).
Michels and Pyle, "Conversion of a Group II Intron into a New Multiple-Turnover Ribozyme that Selectively Cleaves Oligonucleotides: Elucidation of Reaction Mechanism and Structure/Function Relationships," Biochemistry 34:2965-2977 (1995).
Milligan and Uhlenbeck, "Synthesis of Small RNAs Using T7 RNA Polymerase," Methods Enzymol. 180:51-62 (1989).
Nelson and Kurman, Proc. Soc. Exp. Biol. Med. 206:309 (1994).
Nikaido et al., Nature 311:631 (1984).
Noguchi et al., Science 262:1877 (1993).
Noguchi et al., Cell 73:147 (1993).
Nowak, Science 262:1818 (1993).
Nowak, "Xenotransplants Set to Resume," Science 266:1148-1151 (1994).
Ohkawa et al., "Activities of HIV-RNA Targeted Ribozymes Transcribed From a `Shot-Gun` Type Ribozyme-trimming Plasmid," Nucleic Acids Symp. Ser. 27:15-16 (1992).
Ojwang et al., "Inhibition of Human Immunodeficiency Virus Type 1 Expression by a Hairpin Ribozyme," Proc. Natl. Acad. Sci. USA 89:10802-10806 (1992).
Pachecho-Silva et al., Eur. J. Immunol. 22:697 (1992).
Perreault et al., "Mixed Deoxyribo-and Ribo-Oligonucleotides with Catalytic Activity," Nature 344:565-567 (1990).
Perrotta and Been, "Cleavage of Oligoribonucleotides by a Ribozyme Derived from the Hepatitis .delta. Virus RNA Sequence," Biochemistry 31:16-21 (1992).
Pieken et al., "Kinetic Characterization of Ribonuclease-Resistant 2'-Modified Hammerhead Ribozymes," Science 253:314-317 (1991).
Pretolani et al., "Cytokines--Eosinophil Interactions in Experimental Allergy," Cells and Cytokines in Lung Inflammation: Annals of the New York Academy of Sciences 725:247-258 (1994).
Rossi et al., "Ribozymes as Anti-HIV-1 Therapeutic Agents: Principles, Applications, and Problems," Acids Research and Human Retroviruses 8:183-189 (1992).
Rubin and Nelson, Annals. Int. Med. 113:619 (1990).
Russell et al., Science 262:1880 (1993).
Sarver et al., "Ribozymes as Potential Anti-HIV-1 Therapeutic Agents" Science 247:1222-1225 (1990).
Saville and Collins, "A Site-Specific Self-Cleavage Reaction Performed by a Novel RNA in Neurospora Mitochondria," Cell 61;685-696 (1990).
Saville and Collins, "RNA-Mediated Ligation of
McSwiggen James A.
Stinchcomb Dan T.
LeGuyader John L.
Ribozyme Pharmaceuticals Inc.
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