Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1994-10-21
1996-07-02
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4353201, 4351723, 800 2, 800DIG1, 935 24, 935 70, C12N 500, C12N 1500
Patent
active
055321585
ABSTRACT:
A mouse lacking expression of a subunit of the IL-2 receptor in certain cells of the immune system is provided. Also provided are methods of using such mice.
REFERENCES:
Hatakeyama et al., Interleukin-2 Receptor .beta. Chain Gene: Generation of Three Receptor Forms by Cloned Human .alpha. and .beta. Chain cDNA's, Science, vol. 244, pp. 551-556, 5 May 1989.
Hatakeyama et al., A Restricted Cytoplasmic Region of IL-2 Receptor .beta. Chain Is Essential for Growth Signal Transduction but Not for Ligand Binding and Internalization, Cell, vol. 59, pp. 837-845, Dec. 1989.
Hattori et al., Expression of Murine IL-2 Receptor .beta.-Chain on Thymic and Splenic Lymphocyte Subpopulations as Revealed by the IL-2-Induced Proliferative Response in Human IL-2 Receptor .alpha.-Chain Transgenic Mice, J. of Immunol., vol. 144, pp. 3809-3815, No. 10, 1990.
Kono et al., Murine Interleukin 2 Receptor .beta. chain: Dysregulated gene expression in lymphoma line EL-4 caused by a promoter insertion, Proc. Natl. Acad. Sci USA, vol. 87, pp. 1806-1810, Mar. 1990.
Kundig et al., Immune Responses in Interleukin-2-Deficient Mice, Science, vol. 262, pp. 1059-1061, 12 Nov. 1993.
Minami et al., The IL-2 Receptor Complex Its Structure, Function, and Target Genes, Annu. Rev. Immunol, 11:245-67, 1993.
Okino et al., Inhibition of Interleukin-2 Synthesis and Interleukin-2 Receptor .alpha. Expression on T Cells by a Cell-Free Factor Derived from a CD4+ Regulatory T Cell Clone, Clin. Immunol. and Immunopathology, vol. 68, No. 3, pp. 256-262, Sep. 1993.
Schlorle et al., Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting, Letter to Nature, vol. 352, pp. 621-624, Aug. 1991.
Takeuchi et al., Expression and role of interleukin-2 receptor .beta. chain on CD4-CD8+ T cell receptor .alpha..beta.+cells, Eur J. Immunol. 22:2929-2935, 1992.
Tanaka et al., In utero treatment with monoclonal antibody to IL-2 receptor .beta.-chain completely abrogates development of Thy-1+ dendritic epidermal cells, International Immunology, vol. 4, No. 4, pp. 487-491, Dec. 1991.
Tanaka et al., A Novel Monoclonal Antibody Against Murine IL-2 Receptor .beta.-ChainCharacterization of Receptor Expression in Normal Lymphoid Cells and EL-4 Cells, J. of Immunol., vol. 147, No. 7, pp. 2222-2228, Oct. 1991.
Taniguchi et al., The IL-2/IL-2 Receptor System: A Current Overview, Cell, vol. 73, pp. 5-8, Apr. 1993.
Tentori, et al., Essential role of the Interleukin-2-Interleukin 2 Receptor Pathway in Thymocyte Maturation In Vivo, J. Exp. Med., vol. 168, pp. 1741-1747, Nov. 1988.
Thomas A. Waldmann, The IL-2/IL-2 receptor system: a target for rational immune intervention, TiPS, vol. 14, pp. 159-164, May 1993.
Thomas A. Waldmann, The IL-2/IL-2 receptor system: a target for rational immune intervention, Immunology Today, vol. 14, No. 6, pp. 264-270, 1993.
Mak Tak W.
Suzuki Haruhiko
Chambers Jasemine C.
Oleski Nancy A.
Ontario Cancer Institute
LandOfFree
Interleukin-2 receptor deficient mammals does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Interleukin-2 receptor deficient mammals, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Interleukin-2 receptor deficient mammals will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1505962