Interleukin 2 receptor

Details Interleukin 2 receptor Interleukin 2 receptor

1984-05-21

1986-03-25

Kight, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435240, 435241, 435948, 260112R, 2601125R, C12P 2100, C07K 302

Patent

active

045783357

ABSTRACT:
Interleukin-2 receptor derived from normal and malignant cells has been purified by use of various techniques including affinity chromotography in conjunction with a monoclonal antibody directed to the receptor. Purification also involved reversed phased high performance liquid chromotography. By these techniques, interleukin-2 receptor has been purified to homogeneity. The high purification of the interleukin-2 receptor has enabled this protein molecule to be partially sequenced.

REFERENCES:
patent: 4377482 (1983-03-01), Rivier
patent: 4411993 (1983-10-01), Gillis
Third International Lymphokine Workshop: Cell Immunol (70) 1982, pp. 380-409, (only part of reference submitted-pertinent part).
Summary of Third International Lymphokine Workshop; Lymphokine Res. 1(3), 1982.
Smith et al. J. Immunol 131(4), 1983, Production and Characterization of MAB . . . Tactics, p. 1808.
Leonard et al., Nature (300), 1982, p. 267, A Monoclonal Antibody that Appears to Recognize the Receptor for Human T-Cell . . . Receptor.
Robb et al., J. Exp. Med. (158), 1983, p. 1332, Direct Demonstration of the Identity of T-Cell Growth Factor Binding . . . Antigen.

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