Interleukin-2 mutein expressed from mammalian cells

Details Interleukin-2 mutein expressed from mammalian cells Interleukin-2 mutein expressed from mammalian cells

2005-08-09

2005-08-09

Mertz, Prema (Department: 1646)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S325000, C435S358000, C435S320100, C435S471000, C435S070100

Reexamination Certificate

active

06927043

ABSTRACT:
Glycosylated interleukin-2 muteins are described. A method of producing the muteins using mammalian cells is included. The muteins may be incorporated into pharmaceutical preparations useful for, e.g., cancer therapy.

REFERENCES:
patent: 5417970 (1995-05-01), Roskam
patent: 6136599 (2000-10-01), Cho
Konstantinov, et al., Control of Long-Term Perfusion Chinese Hamster Ovary Cell Culture by Glucose Auxost, Biotechnol. Prog., vol. 12, no. 1, 1996, pp. 100-109.
Hu, et al., Large-scale Mammalian Cell Culture, Current Opinion in Biotechnology, vol. 8, 1997, pp. 148-153.

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