Interleukin-2-leukotoxin gene fusions and uses thereof

Details Interleukin-2-leukotoxin gene fusions and uses thereof Interleukin-2-leukotoxin gene fusions and uses thereof

1990-08-22

1993-08-24

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 435 693, 435 695, 435 697, 4351723, 4353201, 4352401, 435243, 4352523, 536 234, 935 22, 935 24, 935 27, 935 47, 935 66, C12P 2102, C07H 1512

Patent

active

052388239

ABSTRACT:
New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of leukotoxin fused to an active fragment of a cytokine. The chimeric proteins can be used in a vaccine composition. Also disclosed are methods of vaccination as well as methods of making the proteins employed in the vaccines.

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