Interleukin-18 (IL-18) receptor polypeptides and their uses

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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530350, 530413, 514 2, 435 71, 435 691, C07K 14715, C12N 1512, A61K 3817, G01N 3353

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active

060871164

ABSTRACT:
The receptor for interleukin-18 (IL-18) is described. The invention provides recombinant receptor polypeptides, including soluble receptors and fusion proteins, which specifically bind to IL-18 and inhibit its activity. The polypeptides are thus useful as pharmaceutical agents to treat autoimmune and allergic diseases. They are also useful as affinity reagents to purify IL-18, in assays to detect the ligand, and in screening assays to identify IL-18 agonists or antagonists.

REFERENCES:
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P. Parnet et al., "IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its holologues T1/ST2 and IL-1R AcP", The Jounal of Biological Chemistry, vol. 271, No. 8, pp 3967-3970, Feb. 23, 1996.
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