Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-12-22
2000-07-11
Fitzgerald, David L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
530350, 530413, 514 2, 435 71, 435 691, C07K 14715, C12N 1512, A61K 3817, G01N 3353
Patent
active
060871164
ABSTRACT:
The receptor for interleukin-18 (IL-18) is described. The invention provides recombinant receptor polypeptides, including soluble receptors and fusion proteins, which specifically bind to IL-18 and inhibit its activity. The polypeptides are thus useful as pharmaceutical agents to treat autoimmune and allergic diseases. They are also useful as affinity reagents to purify IL-18, in assays to detect the ligand, and in screening assays to identify IL-18 agonists or antagonists.
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Kurimoto Masashi
Okura Takanori
Torigoe Kakuji
Fitzgerald David L.
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
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