Interleukin-1 receptor-associated protein kinase and assays

Details Interleukin-1 receptor-associated protein kinase and assays Interleukin-1 receptor-associated protein kinase and assays

1996-01-16

1997-08-05

Jones, W. Gary

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

536 231, 536 243, 435 4, 435 6, C07K 1400, C07H 2104, C12Q 168

Patent

active

056543972

ABSTRACT:
The invention relates to human Interleukin-1 Receptor-Associated Protein Kinases (IRAKs), nucleic acids which encode IRAKs and hybridization probes and primers capable of hybridizing with IRAK genes and methods of using the subject compositions; in particular, methods such as IRAK-based in vitro binding assays and phosphorylation assays for screening chemical libraries for lead compounds for pharmacological agents.

REFERENCES:
Liu et al., Journal of Biological Chemistry 269(4): 3047-3052 (Jan. 1994).
The New England Biolabs Catalog, p. 97 (1993/94 Edition).
Martin et al., Eur. J. Immunology 24: 1566-1571 (1994).
Cao et al., Science 271:1128-1131 (Feb. 1996).
Croston et al., Journal of Biological Chemistry 270(28): 16514-16517 (Jul. 1995).

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