Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1998-04-29
2000-04-25
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
424 852, 530350, 514 2, 514 8, C07K 1452
Patent
active
060545593
ABSTRACT:
IL-1ra beta polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IL-1ra beta polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, septicemia, arthritis, inflammatory bowel disease, graft vs. host disease, autoimmunity, stroke, cardiac ischemia, acute respiratory disease syndrome (ARDS), psoriasis, restenosis, traumatic brain injury, AIDS, cachexia, allergy, parasite infection, allergic rhinitis, allergic asthma, atopic dermatitis, allergic inflammatory diseases, and delayed hypersensitivity., among others, and diagnostic assays for such conditions.
REFERENCES:
patent: 5075222 (1991-12-01), Hannum et al.
patent: 5455330 (1995-10-01), Haskill et al.
patent: 5863769 (1999-01-01), Young
Eisenberg et al., "Primary Structure and Functional Expression from Complementary DNA of a Human Interleukin-1 Receptor Antagonist", Nature, 343, pp. 341-346 (1990).
Auron et al., "Nucleotide Sequence of Human Monocyte Interleukin-1 Precursor cDNA", Proc. Natl. Acad. Sci. USA, 81, pp. 7907-7911, (1984).
C.J. March et al., Nature, 315, pp. 641-647 (1985).
Murray et al., Accession No. G10162, Cooperative Human Linkeage Center, 1995.
Hillier et al., Accession No. N59092, WashU-Merck EST Project, 1995.
Ko, Accession No. T25675, An equalized cDNA library by the reassociation of short double-stranded cDNAs, 1994.
Gu et al., "Activation of Interferon-.gamma. Inducting Factor Mediated by Interleukin-1.beta. Converting Enzyme", Science, 275, pp. 206-209 (1997).
Bazan et al, "A newly defined interluekin-1", Nature, p. 591(1996).
Okamura et al., Cloning of a new cytokine that induces IFN-.gamma. production by T cells:, Nature, 378, pp. 88-91 (1995).
Haskill, et al., "cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium", Proc. Natl. Acad. Sci., 88, pp. 3681-3685 (1991).
Hannum et al., Interleukin-1 receptor antagonist activity of a human interluekin-1 inhibitor:, Nature, 343, pp. 336-340 (1990).
Carter et al., "Purification cloning, expression and biological characterization of an interluekin-1 receptor antagonist protein", Nature, 344, pp. 633-638 (1990).
Draper Garnette D.
Hecht Elizabeth J.
King William T.
SmithKline Beecham Corporation
LandOfFree
Interleukin-1 receptor antagonist beta (IL-1ra.beta.) does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Interleukin-1 receptor antagonist beta (IL-1ra.beta.), we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Interleukin-1 receptor antagonist beta (IL-1ra.beta.) will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-994283