Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-05-08
2000-01-04
Priebe, Scott D.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 43525411, 4353201, 435325, 435410, 536 231, 536 232, 536 235, C12N 1512, C12N 1557, C12N 1563, C07H 2100
Patent
active
060108789
ABSTRACT:
Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility. Antagonists against such ICE LAP-6 and their use as a therapeutic to treat Alzheimer's disease, Parkinson's disease, rheumatoid arthritis, septic shock, sepsis, stroke, chronic inflammation, acute inflammation, CNS inflammation, osteoporosis, ischemia reperfusion injury, cell death associated with cardiovascular disease, polycystic kidney disease, apoptosis of endothelial cells in cardiovascular disease, degenerative liver disease, MS, ALS, cererbellar degeneration, ischemic injury, myocardial infarction, AIDS, myelodysplastic syndromes, aplastic anemia, male pattern baldness, and head injury damage are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the interleukin-1 beta converting enzyme apoptosis proteases and for detecting altered levels of the polypeptide in a host.
REFERENCES:
Duan, et al., "ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas-and Tumor Necrosis Factor-induced Apoptosis", The Journal of Biological Chemistry, 271(3), Jan. 19, 1996, pp. 1621-1625.
Fernandes-Alnemri, et al., "Mch3, a Noval Human Apoptotic Cysteine Protease Highly Related to CPP32.sup.1 ", Cancer Research, 55, pp. 6045-6052, Dec. 15, 1995.
Accession No. H39637, GenBank, Aug. 4, 1995, Hillier, et al., Homo Sapiens cDNA Clone 181983 5'.
Accession No. T975982, GenBank, Apr. 16, 1995, Hillier, et al., Homo Sapiens cDNA Clone 121693 5'.
Duan, et al., "ICE-LAP6, a Novel Member of the ICE/CED-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B", The Journal of Biological Chemistry, 271(28), pp. 16720-16724, Jul. 12, 1996.
Srinivalula, et al., "The Ced-3/Interleukin 1.beta. Converting Enzyme-like Homolog Mch6 and the Lamin-cleaving Enzyme Mch2.alpha. Are Substrates for the Apoptotic Mediator CPP32", The Journal of Biological Chemistry, 271(43), pp. 27099-27106, Oct. 25, 1996.
Orkin et al., "Report and recommendations of the panel to asses the NIH investment in research on gene therapy", issued by the U.S. National Institutes of Health, Dec. 1995.
Ngo et al., "Computational complexity, protein structure prediction, and the Levinthal paradox", in `The Protein Folding Problem and Tertiary Structure Prediction`, Merz et al. (eds.), Birkhauser Boston: Boston, MA, pp. 433 & 492-495, 1994.
Hillier et al., "The WashU-Merck EST Project", GenBank, National Library of Medicine, Accession No. T97582, accessed by PTO Apr. 13, 1998, Mar. 1995.
Fernandes-Alnemri et al., "CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein ced-3 and mammalian interleukin-1 beta-conveying enzyme", J. Biol. Chem. 269(49): 30761-30764, Dec. 1994.
Dixit Vishva M.
He Wei-Wu
Kikly Kristine K.
Ruben Steven M.
Han William T.
King William T.
Priebe Scott D.
SmithKline Beecham Corporation
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