Interleukin-1 .beta. converting enzyme like apoptosis protease-3

Details Interleukin-1 .beta. converting enzyme like apoptosis protease-3 Interleukin-1 .beta. converting enzyme like apoptosis protease-3

1995-06-05

2000-07-11

Sisson, Bradley

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435219, 530300, C12N 964, C07K 1447

Patent

active

060871504

ABSTRACT:
Disclose are human interleukin-1.beta. converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

REFERENCES:
patent: 5552536 (1996-09-01), Nicholson et al.
GeneSeq Accession No: T66992 (Aug. 5, 1997).
GeneSeq Accession No: T66970 (Jul. 21, 1997).
GeneSeq Accession No: T66993 (Aug. 5, 1997).
GeneSeq Accession No: W15247 (Jul. 21, 1997).
GeneSeq Accession No: W15262 (Aug. 5, 1997).
GeneSeq Accession No: W15263 (Aug. 5, 1997).
GenBank Accession No: 39613 (Jan. 10, 1996).
GenBank Accession No: U37448 (Dec. 14, 1995).
GenBank Accession No: U40281 (Jan. 27, 1996).
GenBank Accession No: U67319 (Mar. 19, 1997).
GenBank Accession No: U67320 (Mar. 19, 1997).
GenBank Accession No: U37449 (Dec. 14, 1995).
GenBank Accession No: H91868 (Nov. 29, 1995).
GeneSeq Accession No: T33567 (Dec. 6, 1996).
GeneSeq Accession No: V05471 (Jul. 2, 1998).
GeneSeq Accession No: T32608 (Oct. 26, 1998).
GeneSeq Accession No: V32615 (Oct. 26, 1998).
GeneSeq Accession No: W00677 (Dec. 6, 1996).
GeneSeq Accession No: W00372 (Jun. 26, 1997).
GeneSeq Accession No: W41688 (Jul. 2, 1998).
GeneSeq Accession No: W16600 (Jun. 26, 1997).
GeneSeq Accession No: W48945 (Oct. 26, 1998).
GeneSeq Accession No: W48937 (Oct. 26, 1998).
GenBank Accession No: U26943 (Aug. 29, 1995).
GenBank Accession No: U13737 (Apr. 14, 1995).
GenBank Accession No: U13738 (Apr. 14, 1995).
GenBank Accession No: T10341 (Jun. 7, 1994).
GenBank Accession No: H29199 (Jul. 17, 1995).
GenBank Accession No: N85243 (Apr. 1, 1996).
Walker et al., Cell, vol 78:343-352 (1994).
Wang et al., Cell, vol 78:739-750 (1994).
Tewari et al., Cell, vol 81:801-809 (1995).
Faucheu et al., EMBO Journal, vol 14:1914-1922 (1995).
Greenfeder et al., The J. of Biol. Chem., vol 270:13757-13765 (1995).
Henkart "ICE family proteases: mediators of all apoptotic cell death?" Immunity 4: 195-201, Mar. 1996.
Abstract; WO 9625501-A2, Published Feb. 9, 1996; entitled Pro-Yama cDNA.
Faucheu, Chi et al., The EMBO Journal, vol. 14, No. 9, pp. 1914-1922, 1995.
Greenfeder, Scott A., et al., The Journal of Biological Chemistry, vol. 270, No. 23, Issue of June 9, pp. 13757-13765, 1995.
Walker, N.P.C. et al., Cell, vol. 78, 343-352, Jul. 29, 1994.
Wang, Lin, et al., Cell, vol. 78, 739-750, Sep. 9, 1994.
Fernandez-Alnemri, Teresa, et al., The Journal of Biological Chemistry, vol. 269, No. 49, 1994.
Miura, Masayuki, et al., Cell, vol. 75, 653-660, Nov. 19, 1993.
Barinaga, Marcia, et al., Science, vol. 263, Feb. 11, 1994.
Ellis, Ronald E., et al., Annu. Rev. Cell Biol., 7:663-698, 1991.
Cerretti, Douglas Pat, et al., Science, vol. 256, Apr. 3, 1992.
Kamens; J., et al., The Journal of Biological Chemistry, 270(25):15250-15256 (1995).
Munday, N., et al., The Journal of Biological Chemistry, 270(26):15870-15876 (1995).

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