Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Separation or purification
Patent
1995-04-26
1997-06-24
Fleisher, Mindy
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Separation or purification
424 852, 435 6952, 530351, 530413, 530415, C07K 116, C07K 1454, C12P 2100, A61K 3820
Patent
active
056418680
ABSTRACT:
The present invention relates to compositions containing human interleukin-6 with sugar chains, a process for preparing human interleukin-6 by culturing cells in a medium containing ascorbic acid or any of its derivatives, and a process for purifying a crude raw human interleukin-6 solution by chromatography using a carrier with heparin bound. The present invention has allowed the production of high quality human interleukin-6 compositions with sugar chains, and their application to medicines. Furthermore, it has established a process for massproducing human interleukin-6.
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Hanada Keizo
Hosoi Kazuo
Ichikura Shigeru
Kihara Makoto
Naruto Masanobu
Degen Nancy J.
Fleisher Mindy
Toray Industries Inc.
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