Interlaced lasers for multiple fluorescence measurement

Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample

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356 72, G01N 2164

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active

061398004

ABSTRACT:
An apparatus for detecting at least one receptor in a biological sample in a flow stream for immunoassays, complex genetic analyses, and enzymatic assays. The biological sample includes a carrier having an indicator, such as a fluorescent dye, and a reactant that reacts to the receptor. The indicator indicates a presence of the receptor upon excitation by light having a wavelength or a band of wavelengths. The apparatus includes a viewing chamber for receiving the biological sample in the flow stream and for displaying the same. Light sources are arranged around the viewing chamber so as to emit light sequentially, simultaneously, or substantially simultaneously toward substantially identical or overlapping focal regions in the viewing chamber. At least one optical detector is configured to detect light emitted from the sample responsive to light emitted from the light sources. The apparatus includes band-pass filters for filtering out the emission wavelength reflecting the presence of the receptor and at least one multi-mode fiber optic cable connecting the optical detector to the filters.

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patent: 5260029 (1993-11-01), Hosoi et al.
patent: 5569587 (1996-10-01), Waggoner
patent: 5747349 (1998-05-01), Van den Engh et al.

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