Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1992-12-01
1994-10-25
Hill, Jr., Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530351, 530413, 530414, 530415, 530416, 530417, C07K 1500, A61K 3702
Patent
active
053590325
ABSTRACT:
This invention relates to interleukin inhibitors (IL-1 INHs) that selectively inhibit interleukin 1 activity. The invention also relates to processes for purifying such IL-1 INHs from urine and for producing such IL-1 INHs by hosts transformed with recombinant DNA molecules comprising DNA sequences encoding the inhibitors, and to methods of treatment and compositions characterized by such IL-1 INHs. These methods and agents are useful in immunosuppressive and anti-inflammatory applications and therapies.
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Seckinger, et al., "A Partially Purified Urinary IL-1 Inhibitor That Interferes with IL-1 Binding", Lymphokine Res., 6 Abstr. 1111 (1987).
Seckinger et al., "A Urine Inhibitor Of Interleukin 1 Activity Affects Both Interleukin 1.alpha. and 1.beta. But Not Tumor Necrosis Factor .alpha.", J. Immunol., 139, pp. 1541-1545 (1987).
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Dayer Jean M.
Mazzei Gonzalo J.
Seckinger Philippe L.
Shaw Alan R.
Biogen Inc.
Cermak Shelly Guest
Haley, Jr. James F.
Hill Jr. Robert J.
McDonell Leslie A.
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