Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1984-11-30
1988-06-14
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Lymphokine
530351, 435 68, 435811, A61K 4502, C07K 1300, C07K 1526, C12P 2100
Patent
active
047510773
ABSTRACT:
Human interferons containing novel cysteine substitutions and disulfide bonds are disclosed. The amino acid sequence of a first interferon is combined with the cysteine and/or disulfide pattern of a second interferon resulting in a molecule with hybrid properties.
REFERENCES:
patent: 4414150 (1983-11-01), Goeddel
patent: 4569908 (1986-02-01), Mark et al.
patent: 4588585 (1986-05-01), Mark et al.
Shepard et al., Nature, vol. 294, pp. 563-565, 1981.
Lengyel, Annual Review of Biochemistry, 51:251, 1982.
Wang, A., et al, Science, 224:1431, Jun. 29, 1984.
Thannhauser, T. W., et al, Analytical Biochemistry, 138:181-188, 1984.
Adair John R.
Bell Leslie D.
Porter Alan G.
Smith John C.
G. D. Searle & Co.
Hazel Blondel
Kanady Mary Jo
Matukaitis Paul D.
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