Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-11-14
2006-11-14
Campell, Bruce R. (Department: 1648)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S002600, C530S350000, C530S351000
Reexamination Certificate
active
07135458
ABSTRACT:
A human IFN-γ inducing polypeptide and its nucleotide sequence was isolated, purified and characterized. Pharmaceutical compositions containing this novel IFN-γ inducing polypeptide or active fragments thereof are formulated and monoclonal antibodies are raised against this polypeptide or antigenic fragments thereof. The polypeptide can be used in a method for treating diseases susceptive to treatment with IFN-γ, and methods for enhancing the cytotoxicity of NK cells or for inducing the formation of LAK cells, such as to treat tumors and malignant pathologies.
REFERENCES:
patent: 4645830 (1987-02-01), Yasushi et al.
patent: 4803072 (1989-02-01), Dalton et al.
patent: 4908432 (1990-03-01), Yip
patent: 5004689 (1991-04-01), Fiers et al.
patent: 5147638 (1992-09-01), Esmon et al.
patent: 5218096 (1993-06-01), Shibuya et al.
patent: 5912324 (1999-06-01), Okamura et al.
patent: 6207641 (2001-03-01), Torigoe et al.
patent: 6403079 (2002-06-01), Akita et al.
patent: 6441138 (2002-08-01), Akita et al.
patent: 499112 (1992-08-01), None
patent: 0692536 (1996-01-01), None
patent: 0712931 (1996-07-01), None
patent: 2016015 (1979-09-01), None
patent: 027189 (1996-01-01), None
patent: 193098 (1996-07-01), None
patent: 9205256 (1992-04-01), None
patent: WO 98/10072 (1998-03-01), None
Bowie et al., “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions,” Science, vol. 247, 1306-1310 (1990).
Zhou et al., Journal of Immunology, vol. 155, pp. 785-795 (Jul. 1995).
Wells, Biochemistry, vol. 29 No. 37, pp. 8509-8517 (1990).
Kim et al., Identification of amino acid residues critical for biological activity in human interleukin-18, The Journal of Biological Chemsitry, vol. 277 No. 13, pp. 10998-11003 (Mar. 2002).
XP-002024314, (1993).
Hatt et al., “American Type Culture Collection Catalogue of Cell Lines and Hybridomas”, 5thed., (1985).
Kostura et al., “Identification of A Monocyte Specific Pre-interleukin-18 Convertase Activity”, Proc. Natl. Acad. Sci., 86:5227-5231 (Jul. 1989).
Laemmi, “Cleavage of Structural Proteins During the Assembly of the Head of Bacteriophage T4”, Nature, 227:680-685 (Aug. 15, 1970).
Ushio et al., “Cloning of the cDNA for Human IFN-gamma-Inducing Factor”, Journal of Immunology, 156 (11) :4274-4279, Jun. 1, 1996.
Tijssen, P., “Practice and Theory of Enzyme Immunoassays”, Laboratory techniques in Biochemistry and Molecular Biology; Burden et al (eds) , Elsevier Science Publishers B.V. (Biomedical Division) , (Arsterdam, 1985) (original English language ed.) , pp. 196-197 (1989).
Sevier et al., “Monoclonal Antibodies in Clinical Immunology”, Clinical Chemistry, 27(11) :1797-1806 (1981).
Goding, “Antibody Production by Hybridomas”, Journal of Immunological Methods, 39:285-308 (1980).
Okamura et al., “Cloning of A New Cytokine that Induces IFN-gamma Production by T-cells”, Letters to Nature 378:88-91 (Nov. 2, 1995).
Okamura et al., “A Novel Costimulatory Factor for Gamma Interferon Induction Found in The Livers of Mice Causes Endotoxic Shock”, Infection and Immunity 63 (10) :3966-3972 (Oct. 1995).
Nakamura et al., “Endotoxin-Induced Serum Factor That Stimulates Gamma Interferon Production”, Infection and Immunity 57 (2) :590-95 (Feb. 1989).
Nakamura et al., “Purification of A Factor A Which Provides A Costimulatory Signal for Gamma Interferon Production”, Infection and Immunity 61(1) :64-70 (Jan. 1993).
Johnstone & Thorpe, Immunochemistry in Practice, (1987).
Blackwell, Scientific Publications, Oxford, p. 30.
Blakwill, “Cytokines in Cancer Therapy” Oxford University Press, New York, New York, pp. 1-237 (1989).
Fujioka et al., “Combination of Lymphokine-Oactivated Killer Cells and Interleukin-2 in Treating Metastatic Renal Cell Carcinoma”, British Journal of Urology, 73:23-31 (1994).
Sambrook et al., “Molecular Cloning. A Laboratory Manual” 2ndEdition, Cold Spring Harbor Laboratory Press, Xi-xxxviii (1989).
Japan Abstract 05279376, Oct. 26, 1993.
Fukuda Shigeharu
Kohno Keizo
Kunikata Toshio
Kurimoto Masashi
Okamura Haruki
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
Lucas Zachariah
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