Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Patent
1991-12-06
1996-07-30
Chan, Christina Y.
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
424 854, 424 856, 530351, C12N 1500, C12P 2102, C12Q 168, A01N 107
Patent
active
055409237
ABSTRACT:
The invention relates to a method for producing isolating and purifying trophoblast interferon proteins such as .beta.-interferons, .alpha..sub.I -interferon proteins, .alpha..sub.II -interferon proteins, and .gamma.-interferon proteins, and to a method of using the interferon proteins, e.g. for inhibiting tumoral growth or metastatic processes, for preventing graft-versus-host reaction, against leukemia, against viral activity, and against infection of the placenta; as well as antibodies against the interferon proteins.
REFERENCES:
patent: 4992271 (1991-02-01), Fernandez et al.
G. Aboagye-Mathiesen et al., Characterization of Sendai Virus-Induced Human Placental Trophoblast Interferons Journal of General Virology, 72, pp. 1-5, (1991).
T. Y. Basham et al., Recombinant Interferon-.gamma. Increases HLA-DR Synthesis and Expression, The Journal of Immunology, 130:4, pp. 1492-1494, (1983).
B. H. Butterworth et al., Human Cytotrophoblast Populations Studied by Monoclonal Antibodies Using Single and Double Biotin-Avidin-Peroxidase Immunocytochemistry, The Journal of Histochemistry and Cytochemistry, 33:10, pp. 977-983, (1985).
W. L. Farrar et al., Interleukin--2 Stimulates Association of Protein Kinase C with Plasma Membrane, Nature, 315, pp. 233-235.
W. P. Faulk et al., Human Placentae: View From an Immunological Bias, American Journal of Reproductive Immunology, 21, pp. 108-113.
W. P. Faulk et al., Distribution of .beta..sub.2 Microglobulin and HLA in Chorionic Villi of Human Placentae, Nature, 626, pp. 799-802.
M. A. Feinman et al., HLA Antigen Expression and Induction by .gamma.-Interferon in Cultured Human Trophoblasts, American Journal of Obstetrics and Gynecology, 157:6, pp. 1429-1434.
D. C. Flyer et al., Retrovirus-Induced Changes in Major Histocompatibility Complex Antigen Expression Influence Susceptibility to Lysis by Cytotoxic T Lymphocytes, The Journal of Immunology, 135:4, pp. 2287-2292.
N. Harboe et al., Immunization, Isolation of Immunoglobulins, Estimation of Antibody Titre, Scandinavian Journal of Immunology, 2 (Supp 1), pp. 161-164.
J. S. Hunt et al., Interferon--Induces Class I HLA and .beta..sub.2 -Microglobulin Expression by Human Amnion Cells, The Journal of Immunology, 136:2, pp. 364-367.
H. M. Johnson et al., Vasopressin Replacement of Interleukin 2 Requirement in Gamma Interferon Production: Lymphokine Activity of a Neuroendocrine Hormone, The Journal of Immunology, 129:3, pp. 983-986.
H. M. Johnson et al., Cyclic GMP as the Second Messenger in Helper Cell Requirement for .gamma.-Interferon Production, The Journal of Immunology, 129:6, pp. 2570-2572.
H. M. Johnson et al., Leukotrienes: Positive Signals for Regulation of .gamma.-Interferon Production, The Journal of Immunology, 132:1, pp. 413-416.
M. Kato et al., Expression of HLA Class I and .beta..sub.2 -Microglobulin on Human Choriocarcinoma Cell Lines: Induction of HLA Class I by Interferon-.gamma., Placenta, 12, pp. 217-226.
C. Kohler et al., Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity, Nature, 256, pp. 495-497.
L. A. Matis et al., Magnitude of Response of Histocompatibility-Restricted T-Cell Clones is a Funciton of the Product of the Concentrations of Antigen and Ia Molecules, Proceeding of National Academy of Science, USA, 80, pp. 6019-6023.
R. Mattsson et al., Placental HMC Claa I Antigen Expression is Induced in Mice Following in Vivo Treatment with Recombinant Interferon-Gamma, Journal of Reproductive Immunology, 19, pp. 115-129.
V. Papermaster et al., Evidence for Suppressor T-Cell Regulation of Human Gamma Interferon Production, Cellular Immunology, 79, pp. 279-287.
L. Paulesu et al., Immunocytochemical Localization of Interferons in Human Trophoblast Populations, Journal of Biological Regulators and Homeostatic Agents, 5:3, pp. 81-85.
C. W. G. Redman et al., Class 1 Major Histocompatibility Complex Antigens on Human Extra-Villous Trophoblast, Immunology, 52, pp. 457-468.
P. S. Steeg et al., Regulation of Murine Macrophage Ia Antigen Expression by a Lymphokine with Immune Interferon Activity, Journal of Experimental Medicine, 156, pp. 1780-1793.
B. A. Torres et al., Interleukin 2 Regulates Immune Interferon (IFN.gamma.) Production by Normal and Suppressor Cell Cultures, The Journal of Immunology, 128:5, pp. 2217-2219.
F. D. Toth et al., Human Trophoblast Interferon: Pattern of Response to Priming and Superinduction of Purified Term Trophoblast and Choriocarcinoma Cells, Journal of Reproductive Immunology, 19, pp. 55-67.
E. R. Unanue et al., Antigen Presentation: Comments on Its Regulation and Mechanism, The Journal of Immunology 132:1, pp. 1-5.
D. Wallach et al., Preferential Effect of .gamma. Interferon on the Synthesis of HLA Antigens and their mRNAs in Human Cells, Nature, 229, pp. 833-836.
D. A. Weigent et al., Recombinant Gamma Interferon Enhances Natural Killer Cell Activity Similar to Natural Gamma Interferon, Biochemical and Biophysical Research Communications, 111:2, pp. 525-529.
F. Aiuti et al., Identification, Enumeration, and Isolation of B and T Lymphocytes from the Human Peripheral Blood, (W.H.O. Workshop, 1974), Scandinavian Journal of Immunology, 3, pp. 521-532.
Aboagye-Mathiesen et al, "Purification of human placenta trophoblast . . . higher performance liquid chromotography", Prep. Biochem, vol. 21 (1)pp. 35-51 (1991). (Abstract).
M. K. Rosenblum et al., Growth Inhibitory Effects of Interferon-.beta. but Not Interferon-.alpha. on Human Glioma Cells: Receptor Binding, 2',5'-Oligoadenylate Synthetase and Protein Kinase Activity, Journal of Interferon Research, 10:141-151, (1990).
Irene Athanassakis, et al., The Immunostimulatory Effect of T Cells and T Cell Lymphokines on Murine Fetally Derived Placental Cells, The Journal of Immunology, 138, pp. 37-44, (1987).
F. Dianzani et al., A New Type of Human Interferon Produced by Peripheral Blood Mononuclear Cells Treated with Inhibitors of Transcription, Journal of Interferon Research, 6, pp. 43-50, (1986).
G. C. Douglas et al., Isolation of Pure Villous Cytotrophoblast from Term Human Placenta Using Immunomagnetic Micropheres, Journal of Immunological Methods, 119, pp. 259-268, (1989).
Gordon C. Douglas et al., Differentiation of Human Trophoblast Cells in Vitro as Revealed by Immunocytochemical Staining of Desmoplakin an Nuclei, Journal of Cell Science, 96, pp. 131-141, (1990).
Susan J. Fisher et al., Adhesive and Degradative Properties of Human Placental Cytotrophoblast Cells in vitro, The Journal of Cell Biology, 109, pp. 891-902, (1989).
A. G. Howatson et al., Localization of .alpha.-Interferon in the Human Feto-Placental Unit, Journal of Endocrinology, 119, pp. 531-534, (1988).
U. K. Laemmli, Cleavage of Structural Proteins during the Assembly of the Head Bacteriophage T4, Nature, 227, pp. 680-685, (1970).
P. Lebon et al., The Presence of .alpha.-Interferon in Human Amniotic Fluid, Journal of Virology, 59, pp. 393-396, (1982).
Tim Mosmann, Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays, Journal of Immunological Methods, 65, pp. 55-63, (1983).
F. D. Toth et al., Interferon Production by Cultured Human Trophoblast Induced with Double Stranded Poly-ribonucleotide, Journal of Reproductive Immunology, 17, pp. 217-227, (1990).
Paulette Duc-Goiran et al., Unusual Apparently Constitutive Interferons and Antagonist in Human Placental Blood, Proceedings of the National Academy of Science U.S.A., 82, pp. 5010-5014, (1985).
J. O. Klein et al., An Introduction to Infection of the Fetus and Newborn Infant, Infectious Disease of the Fetus and Newborn, pp. 1-32.
P. B. Fisher et al., Effects of Interferons on Differentiation of Normal and Tumor Cells, Pharmacology and Therapeutics, 27, pp. 143-166.
Terry W. Chin et al., Enhanced Interferon Production and Lymphokine-activated cytotoxicity of human placenta cells, Cellular Immunology, 113, pp. 1-9.
Rudolf Hauptmann et al., A Novel Class of Human Type I Interferons, Nucleic Acids Research, 13, pp. 4739-4749.
J. C. Correttini et al., Inhibitory Effect of Interferon Preparations and Inducers on Multipli
Aboagye-Mathiesen George
Ebbesen Peter
Toth Ferenc D.
Chan Christina Y.
Cooper Iver P.
Landsforeningen til Kraeftens Bekaemplse
Touzeau Lynn
LandOfFree
Interferon proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Interferon proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Interferon proteins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1656479