Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Patent
1995-11-21
1998-04-14
Sayala, Chhaya D.
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
530402, A61K 3821
Patent
active
057388466
ABSTRACT:
Interferon-polymer conjugate containing compositions having high levels of retained interferon activity and relatively long circulating lives in vivo are disclosed. The compositions contain a mixture of mono-interferon-polymer conjugates and bis-interferon-polymer conjugates, with both species containing substantially a single polymer strand. The conjugate compositions are prepared by reacting about 1 mole of an interferon with from about 0.125 to about 1 mole of a bis-activated substantially non-antigenic polymer under conditions sufficient to effect covalent conjugation of the interferon and polymer. Methods of treating interferon-susceptible conditions with the compositions of the present invention are also disclosed.
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Gilbert Carl W.
Greenwald Richard B.
Enzon Inc.
Sayala Chhaya D.
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