Interferon-inducible protein 10 is a potent inhibitor of angioge

Details Interferon-inducible protein 10 is a potent inhibitor of angioge Interferon-inducible protein 10 is a potent inhibitor of angioge

1995-05-31

1999-11-30

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 4, 514 12, 514 21, 530300, 530324, 530325, 530326, 530327, 530328, A61K 3800

Patent

active

059942924

ABSTRACT:
The present invention is interferon-inducible protein 10 and fragments and analogs of interferon-inducible protein 10 as inhibitors of angiogenesis. The present invention is also the use of interferon-inducible protein 10 (IP-10) as well as fragments and analogs of IP-10 as potent inhibitors of angiogenesis. IP-10 profoundly inhibited basic fibroblast growth factor (bFGF)-induced neovascularization in immunocompromised mammals. In addition, IP-10, is useful in a dose-dependent fashion in suppressing endothelial cell differentiation into tubular capillary structures.

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