Interferon inducer and method of preparing same

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...

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424 85, 435 91, 435194, 435815, 435816, 536 28, 435948, A01N 900, C12P 1934

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043139388

ABSTRACT:
Double-stranded RNA synthesized using native human DNA as template is found to be an excellent interferon inducer with low toxicity in spite of homologous native to host cell. It is produced by reacting ATP, GTP, CTP and UTP with one another in the presence of a native human DNA as template by the catalytic action of an active RNA polymerase to form RNA and subjecting the resulting RNA to annealing by heating it at a temperature of 70.degree. to 100.degree. C. and gradually cooling to room temperature or below to form double-stranded regions between their molecules.

REFERENCES:
patent: 3819482 (1974-06-01), Vidaver et al.
patent: 4082613 (1978-04-01), Thirumalachar et al.
Microbiology, Davis et al., Harper & Rowe, Publishers, pp. 1398-1405 (1968).
Methods in Enzymology, vol. XXX, Part F, Moldave et al., pp. 654-661 (1974).

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