Interferon-induced human protein in pure form, monoclonal antibo

Details Interferon-induced human protein in pure form, monoclonal antibo Interferon-induced human protein in pure form, monoclonal antibo

1991-12-19

1993-03-30

Martinell, James

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

4351723, 43524027, 536 235, 530350, 5303879, 5303882, C12P 1934, C12N 1500, C12N 1512

Patent

active

051983508

ABSTRACT:
The invention relates to purified proteins induced in human cells by interferon .alpha. or .beta., RNAs, DNAs and hybrid vectors coding for said proteins, hosts transformed with such a hybrid vector, processes for the preparation and purification of these proteins, DNAs, vectors and hosts, monoclonal antibodies specific to these proteins, monoclonal antibody derivatives, hybridoma cell lines secreting these monoclonal antibodies, the use of the monoclonal antibodies and their derivatives in the qualitative and quantitative determination of these proteins, test kits containing the monoclonal antibodies, and pharmaceutical preparations containing said proteins. A protein of the invention shows antiviral properties ascribed to interferons and may be a valuable indicator of the cell response to an interferon therapy.

REFERENCES:
Chebath, J., et al., Nucleic Acid Research, vol. 11, pp. 1213-1226, 1983.
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H. L. Cooper, FEBS Letters 140, 109 (1982).
A. Gustafsson et al, J. Of Immunology 129, 1952 (1982).
A. G. Laurent et al., Proc. Natl. Acad. Sci. USA 82, 4341 (1985).
P. Staeheli and O. Haller, Mol. and cellular Biology 5, 2150 (1985).
P. Staeheli et al., Cell 44, 147 (1986).
Stacheli et al., Biol. Interferon Syst. Proc. TNO-ISIR Meeting-Interferon Sep. 4, 1985, 115-118, 1986.
P. Staeheli et al., J. Biol. Chem. 260, 1821 (1985).
M. A. Horisberger et al., J. Interferon Res. vol. 7, p. 675 (1987).
M. A. Horisberger et al. J. Interferon Res., vol. 7, p. 331 (1987).

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